MIR4722

Summary

MIR4722 (microRNA 4722, HGNC:41782) is a microRNA gene on chromosome 16q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616167 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41782
Approved symbol	MIR4722
Name	microRNA 4722
Location	16q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4722
Ensembl gene	ENSG00000284585
Ensembl biotype	miRNA
Entrez	100616167
RNAcentral	URS000075BF79 — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578292

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578292 — 1 exons

Exon	Start	End
ENSE00002713222	88716278	88716337

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 87.55.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	87.55	gold quality
lymph node	UBERON:0000029	85.82	gold quality
vermiform appendix	UBERON:0001154	85.12	gold quality
granulocyte	CL:0000094	82.00	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.65	gold quality
bone marrow	UBERON:0002371	79.70	gold quality
adrenal tissue	UBERON:0018303	79.25	gold quality
rectum	UBERON:0001052	78.22	gold quality
blood	UBERON:0000178	77.95	gold quality
placenta	UBERON:0001987	76.60	gold quality
left uterine tube	UBERON:0001303	75.90	gold quality
monocyte	CL:0000576	75.23	gold quality
muscle of leg	UBERON:0001383	75.01	gold quality
gastrocnemius	UBERON:0001388	74.81	gold quality
heart left ventricle	UBERON:0002084	74.81	gold quality
calcaneal tendon	UBERON:0003701	74.43	gold quality
lung	UBERON:0002048	73.59	gold quality
upper lobe of left lung	UBERON:0008952	72.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.82	gold quality
adipose tissue	UBERON:0001013	72.77	gold quality
skin of abdomen	UBERON:0001416	72.69	gold quality
endometrium	UBERON:0001295	72.64	gold quality
zone of skin	UBERON:0000014	72.49	gold quality
omental fat pad	UBERON:0010414	72.45	gold quality
skin of leg	UBERON:0001511	72.32	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.96	gold quality
body of stomach	UBERON:0001161	71.88	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.86	gold quality
mucosa of stomach	UBERON:0001199	71.82	gold quality
lower esophagus	UBERON:0013473	71.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.04

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.