MIR4723

Summary

MIR4723 (microRNA 4723, HGNC:41660) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616388 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41660
Approved symbol	MIR4723
Name	microRNA 4723
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4723
Ensembl gene	ENSG00000284532
Ensembl biotype	miRNA
Entrez	100616388
RNAcentral	URS000075B42B — ncRNA, 81 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585070

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585070 — 1 exons

Exon	Start	End
ENSE00002715861	28360654	28360734

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 69.55.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	69.55	gold quality
nucleus accumbens	UBERON:0001882	67.67	gold quality
left adrenal gland	UBERON:0001234	66.76	gold quality
right adrenal gland	UBERON:0001233	66.44	gold quality
body of stomach	UBERON:0001161	66.16	gold quality
tibial artery	UBERON:0007610	65.45	gold quality
blood	UBERON:0000178	64.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.54	gold quality
body of pancreas	UBERON:0001150	62.10	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	61.13	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.19	gold quality
spleen	UBERON:0002106	56.95	gold quality
upper lobe of left lung	UBERON:0008952	56.89	gold quality
cerebellar hemisphere	UBERON:0002245	55.36	gold quality
skin of leg	UBERON:0001511	53.83	gold quality
tibial nerve	UBERON:0001323	53.06	gold quality
skin of abdomen	UBERON:0001416	49.53	gold quality
body of uterus	UBERON:0009853	45.81	gold quality
vagina	UBERON:0000996	43.58	gold quality
left testis	UBERON:0004533	31.58	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MiR-4723 expression led to dramatic induction of apoptosis in prostate cancer cell lines suggesting that miR-4723 is a pro-apoptotic miRNA regulating prostate carcinogenesis. (PMID:24223753)
• The role of microRNA-4723-5p regulated by c-myc in triple-negative breast cancer. (PMID:35382692)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.