MIR4724

Summary

MIR4724 (microRNA 4724, HGNC:41590) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616248 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41590
Approved symbol	MIR4724
Name	microRNA 4724
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4724
Ensembl gene	ENSG00000284424
Ensembl biotype	miRNA
Entrez	100616248
RNAcentral	URS000075EEE9 — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579485

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579485 — 1 exons

Exon	Start	End
ENSE00002690638	31534883	31534971

Expression profiles

Bgee: expression breadth broad, 27 present calls, max score 77.19.

Top tissues by expression

27 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	77.19	gold quality
heart left ventricle	UBERON:0002084	75.27	gold quality
small intestine	UBERON:0002108	74.80	gold quality
gastrocnemius	UBERON:0001388	73.19	gold quality
blood	UBERON:0000178	68.81	gold quality
colon	UBERON:0001155	68.56	gold quality
lung	UBERON:0002048	67.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.16	gold quality
endometrium	UBERON:0001295	67.05	gold quality
vermiform appendix	UBERON:0001154	66.03	gold quality
body of uterus	UBERON:0009853	64.86	gold quality
tibial artery	UBERON:0007610	62.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.77	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.76	gold quality
left lobe of thyroid gland	UBERON:0001120	60.96	gold quality
skin of leg	UBERON:0001511	59.54	gold quality
upper lobe of left lung	UBERON:0008952	58.87	gold quality
right atrium auricular region	UBERON:0006631	56.38	gold quality
islet of Langerhans	UBERON:0000006	56.36	gold quality
ascending aorta	UBERON:0001496	56.31	gold quality
omental fat pad	UBERON:0010414	55.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.01	gold quality
tibial nerve	UBERON:0001323	54.25	gold quality
esophagus mucosa	UBERON:0002469	53.50	gold quality
prostate gland	UBERON:0002367	45.50	gold quality
urinary bladder	UBERON:0001255	42.86	gold quality
right ovary	UBERON:0002118	39.29	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.