MIR4725

Summary

MIR4725 (microRNA 4725, HGNC:41608) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616449 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41608
Approved symbol	MIR4725
Name	microRNA 4725
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4725
Ensembl gene	ENSG00000265976
Ensembl biotype	miRNA
Entrez	100616449
RNAcentral	URS000075A8E3 — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581700

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581700 — 1 exons

Exon	Start	End
ENSE00002732220	31575269	31575358

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 78.56.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.56	gold quality
liver	UBERON:0002107	73.75	gold quality
adrenal tissue	UBERON:0018303	73.39	gold quality
heart	UBERON:0000948	72.39	gold quality
stomach	UBERON:0000945	72.18	gold quality
heart left ventricle	UBERON:0002084	72.14	gold quality
calcaneal tendon	UBERON:0003701	71.73	gold quality
gastrocnemius	UBERON:0001388	71.65	gold quality
left coronary artery	UBERON:0001626	71.36	gold quality
blood	UBERON:0000178	70.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.80	gold quality
body of stomach	UBERON:0001161	70.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.64	gold quality
endometrium	UBERON:0001295	68.63	gold quality
body of pancreas	UBERON:0001150	68.44	gold quality
right lobe of liver	UBERON:0001114	67.84	gold quality
ascending aorta	UBERON:0001496	67.79	gold quality
putamen	UBERON:0001874	67.75	gold quality
thoracic aorta	UBERON:0001515	67.67	gold quality
omental fat pad	UBERON:0010414	67.57	gold quality
adipose tissue	UBERON:0001013	67.02	gold quality
tibial artery	UBERON:0007610	66.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.82	gold quality
skin of abdomen	UBERON:0001416	66.38	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.21	gold quality
colon	UBERON:0001155	65.99	gold quality
esophagus mucosa	UBERON:0002469	65.94	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.91	gold quality
zone of skin	UBERON:0000014	65.89	gold quality
thoracic mammary gland	UBERON:0005200	65.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• this study showed that the mir-4725-3p targeting stromal interacting molecule 1 signaling is involved in xanthohumol inhibition of glioma cell invasion. (PMID:29747239)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.