MIR4726

Summary

MIR4726 (microRNA 4726, HGNC:41722) is a microRNA gene on chromosome 17q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616153 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41722
Approved symbol	MIR4726
Name	microRNA 4726
Location	17q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4726
Ensembl gene	ENSG00000273627
Ensembl biotype	miRNA
Entrez	100616153
RNAcentral	URS000075BEDC — ncRNA, 58 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615971

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615971 — 1 exons

Exon	Start	End
ENSE00003731691	38719691	38719748

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 76.84.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.84	gold quality
gastrocnemius	UBERON:0001388	74.85	gold quality
adult mammalian kidney	UBERON:0000082	74.21	gold quality
heart left ventricle	UBERON:0002084	73.80	gold quality
body of pancreas	UBERON:0001150	71.83	gold quality
stomach	UBERON:0000945	70.69	gold quality
body of stomach	UBERON:0001161	70.59	gold quality
tibial artery	UBERON:0007610	69.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.13	gold quality
omental fat pad	UBERON:0010414	68.86	gold quality
left ovary	UBERON:0002119	68.79	gold quality
liver	UBERON:0002107	68.77	gold quality
thoracic mammary gland	UBERON:0005200	68.63	gold quality
right lobe of liver	UBERON:0001114	68.44	gold quality
amygdala	UBERON:0001876	68.44	gold quality
lung	UBERON:0002048	68.29	gold quality
right atrium auricular region	UBERON:0006631	68.22	gold quality
fundus of stomach	UBERON:0001160	68.04	gold quality
minor salivary gland	UBERON:0001830	68.04	gold quality
left adrenal gland	UBERON:0001234	68.02	gold quality
left adrenal gland cortex	UBERON:0035825	67.95	gold quality
colon	UBERON:0001155	67.75	gold quality
transverse colon	UBERON:0001157	67.56	gold quality
myometrium	UBERON:0001296	67.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.41	gold quality
esophagus mucosa	UBERON:0002469	67.36	gold quality
right adrenal gland cortex	UBERON:0035827	67.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.33	gold quality
caudate nucleus	UBERON:0001873	67.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.