MIR4727

Summary

MIR4727 (microRNA 4727, HGNC:41709) is a microRNA gene on chromosome 17q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616416 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41709
Approved symbol	MIR4727
Name	microRNA 4727
Location	17q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4727
Ensembl gene	ENSG00000274054
Ensembl biotype	miRNA
Entrez	100616416
RNAcentral	URS000075A17A — ncRNA, 55 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622232

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622232 — 1 exons

Exon	Start	End
ENSE00003729330	38825838	38825892

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 81.11.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	81.11	gold quality
adrenal tissue	UBERON:0018303	80.96	gold quality
putamen	UBERON:0001874	80.06	gold quality
blood	UBERON:0000178	78.52	gold quality
stomach	UBERON:0000945	77.46	gold quality
adult mammalian kidney	UBERON:0000082	75.93	gold quality
gastrocnemius	UBERON:0001388	74.65	gold quality
monocyte	CL:0000576	74.48	gold quality
islet of Langerhans	UBERON:0000006	72.29	gold quality
spleen	UBERON:0002106	70.92	gold quality
anterior cingulate cortex	UBERON:0009835	70.58	gold quality
thyroid gland	UBERON:0002046	70.34	gold quality
lung	UBERON:0002048	70.33	gold quality
intestine	UBERON:0000160	69.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.45	gold quality
tibial artery	UBERON:0007610	68.81	gold quality
endometrium	UBERON:0001295	68.80	gold quality
right frontal lobe	UBERON:0002810	68.62	gold quality
esophagus mucosa	UBERON:0002469	68.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.10	gold quality
ascending aorta	UBERON:0001496	67.87	gold quality
amygdala	UBERON:0001876	67.61	gold quality
colon	UBERON:0001155	67.55	gold quality
omental fat pad	UBERON:0010414	67.44	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.23	gold quality
transverse colon	UBERON:0001157	67.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.80	gold quality
prostate gland	UBERON:0002367	66.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.