MIR4728

Summary

MIR4728 (microRNA 4728, HGNC:41632) is a microRNA gene on chromosome 17q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616132 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41632
Approved symbol	MIR4728
Name	microRNA 4728
Location	17q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4728
Ensembl gene	ENSG00000265178
Ensembl biotype	miRNA
Entrez	100616132
RNAcentral	URS000075CDD2 — ncRNA, 67 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580969

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580969 — 1 exons

Exon	Start	End
ENSE00002697829	39726495	39726561

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 95.86.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.86	gold quality
right uterine tube	UBERON:0001302	90.52	gold quality
lower esophagus mucosa	UBERON:0035834	87.64	gold quality
duodenum	UBERON:0002114	86.31	gold quality
apex of heart	UBERON:0002098	84.57	gold quality
metanephros cortex	UBERON:0010533	82.84	gold quality
tibial nerve	UBERON:0001323	82.41	gold quality
lymph node	UBERON:0000029	82.21	gold quality
mucosa of transverse colon	UBERON:0004991	81.84	gold quality
right lobe of thyroid gland	UBERON:0001119	81.66	gold quality
fundus of stomach	UBERON:0001160	80.86	gold quality
kidney	UBERON:0002113	80.51	gold quality
esophagus mucosa	UBERON:0002469	80.50	gold quality
skin of leg	UBERON:0001511	80.42	gold quality
saliva-secreting gland	UBERON:0001044	80.34	gold quality
zone of skin	UBERON:0000014	80.22	gold quality
minor salivary gland	UBERON:0001830	80.21	gold quality
skin of abdomen	UBERON:0001416	80.03	gold quality
calcaneal tendon	UBERON:0003701	79.82	gold quality
left lobe of thyroid gland	UBERON:0001120	79.63	gold quality
adult mammalian kidney	UBERON:0000082	79.50	gold quality
vagina	UBERON:0000996	79.46	gold quality
thyroid gland	UBERON:0002046	79.09	gold quality
prostate gland	UBERON:0002367	78.98	gold quality
endometrium	UBERON:0001295	78.78	gold quality
transverse colon	UBERON:0001157	78.16	gold quality
placenta	UBERON:0001987	78.15	gold quality
rectum	UBERON:0001052	77.97	gold quality
esophagus	UBERON:0001043	77.36	gold quality
right atrium auricular region	UBERON:0006631	76.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• MiR-4728-3p has alternative functionalities. (PMID:24828673)
• mir-4728, an intron of the ErbB2 gene, is a negative regulator of MAPK signaling through directly targeting the ERK upstream kinase MST4 and exerts numerous tumor-suppressive properties (PMID:25950472)
• MiR-4728-3p and miR-4728-5p were significantly up-regulated in HER2-positive patients compared with HER2-negative breast cancer patients. (PMID:26406406)
• this study shows that a miR-4728 downregulates PADI2, a novel rheumatoid arthritis risk gene (PMID:26927695)
• this study shows that HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5 (PMID:27752128)
• Low miR-4728 expression is associated with Ulcerative Colitis-associated Colorectal Neoplasia. (PMID:28594651)
• Studied association of coamplification of microRNA 4728 and HER2 inhibitor resistance in HER2 amplified breast cancers. (PMID:29476008)
• Long noncoding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR47285p/OGG1 axis. (PMID:33000245)
• HER2-intronic miR-4728-5p facilitates HER2 expression and accelerates cell proliferation and migration by targeting EBP1 in breast cancer. (PMID:33529238)
• [miR-485-3p and miR-4728-5p as Tumor Suppressors in Pathogenesis of Colorectal Cancer]. (PMID:35621109)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.