MIR4729

Summary

MIR4729 (microRNA 4729, HGNC:41585) is a microRNA gene on chromosome 17q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616204 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41585
Approved symbol	MIR4729
Name	microRNA 4729
Location	17q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4729
Ensembl gene	ENSG00000263857
Ensembl biotype	miRNA
Entrez	100616204
RNAcentral	URS000075B85E — ncRNA, 72 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584140

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584140 — 1 exons

Exon	Start	End
ENSE00002693987	59366083	59366154

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 95.10.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.10	gold quality
prefrontal cortex	UBERON:0000451	85.58	gold quality
corpus callosum	UBERON:0002336	84.15	gold quality
blood	UBERON:0000178	81.18	gold quality
liver	UBERON:0002107	80.34	gold quality
kidney	UBERON:0002113	80.32	gold quality
bone marrow	UBERON:0002371	80.06	gold quality
adrenal tissue	UBERON:0018303	78.76	gold quality
stomach	UBERON:0000945	77.04	gold quality
monocyte	CL:0000576	76.59	gold quality
calcaneal tendon	UBERON:0003701	75.78	gold quality
adult mammalian kidney	UBERON:0000082	74.50	gold quality
muscle of leg	UBERON:0001383	74.20	gold quality
gastrocnemius	UBERON:0001388	72.70	gold quality
islet of Langerhans	UBERON:0000006	72.24	gold quality
heart	UBERON:0000948	70.56	gold quality
anterior cingulate cortex	UBERON:0009835	70.52	gold quality
endometrium	UBERON:0001295	69.78	gold quality
intestine	UBERON:0000160	69.37	gold quality
left coronary artery	UBERON:0001626	68.83	gold quality
heart left ventricle	UBERON:0002084	68.47	gold quality
lung	UBERON:0002048	68.22	gold quality
right atrium auricular region	UBERON:0006631	67.81	gold quality
colon	UBERON:0001155	67.77	gold quality
right lobe of liver	UBERON:0001114	67.73	gold quality
right coronary artery	UBERON:0001625	67.66	gold quality
multicellular organism	UBERON:0000468	67.62	gold quality
ascending aorta	UBERON:0001496	67.29	gold quality
popliteal artery	UBERON:0002250	67.11	gold quality
body of stomach	UBERON:0001161	66.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.