MIR4730

Summary

MIR4730 (microRNA 4730, HGNC:41880) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616359 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41880
Approved symbol	MIR4730
Name	microRNA 4730
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4730
Ensembl gene	ENSG00000264961
Ensembl biotype	miRNA
Entrez	100616359
RNAcentral	URS000075CB67 — ncRNA, 76 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584535

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584535 — 1 exons

Exon	Start	End
ENSE00002727235	80419418	80419493

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 85.97.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	85.97	gold quality
duodenum	UBERON:0002114	83.74	gold quality
vermiform appendix	UBERON:0001154	82.09	gold quality
bone marrow	UBERON:0002371	81.51	gold quality
placenta	UBERON:0001987	80.21	gold quality
prefrontal cortex	UBERON:0000451	79.00	gold quality
right hemisphere of cerebellum	UBERON:0014890	78.40	gold quality
cerebellar hemisphere	UBERON:0002245	77.54	gold quality
endometrium	UBERON:0001295	75.55	gold quality
muscle of leg	UBERON:0001383	75.30	gold quality
lymph node	UBERON:0000029	75.22	gold quality
blood	UBERON:0000178	74.96	gold quality
gastrocnemius	UBERON:0001388	74.68	gold quality
adult mammalian kidney	UBERON:0000082	74.49	gold quality
monocyte	CL:0000576	74.32	gold quality
apex of heart	UBERON:0002098	74.31	gold quality
kidney	UBERON:0002113	73.38	gold quality
heart left ventricle	UBERON:0002084	73.19	gold quality
smooth muscle tissue	UBERON:0001135	72.77	gold quality
stomach	UBERON:0000945	72.44	gold quality
granulocyte	CL:0000094	72.39	gold quality
body of pancreas	UBERON:0001150	72.35	gold quality
right ovary	UBERON:0002118	72.24	gold quality
rectum	UBERON:0001052	72.20	gold quality
gall bladder	UBERON:0002110	72.12	gold quality
fundus of stomach	UBERON:0001160	71.96	gold quality
body of stomach	UBERON:0001161	71.89	gold quality
heart	UBERON:0000948	71.80	gold quality
right coronary artery	UBERON:0001625	71.78	gold quality
myometrium	UBERON:0001296	71.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Hsa-miR-4730 as a new and potential diagnostic and prognostic indicators for pancreatic cancer. (PMID:32964968)
• miR4730 suppresses the progression of liver cancer by targeting the high mobility group A1 pathway. (PMID:35485281)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.