MIR4731

Summary

MIR4731 (microRNA 4731, HGNC:41597) is a microRNA gene on chromosome 17p12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616125 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41597
Approved symbol	MIR4731
Name	microRNA 4731
Location	17p12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4731
Ensembl gene	ENSG00000265110
Ensembl biotype	miRNA
Entrez	100616125
RNAcentral	URS000075A4A3 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580859

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580859 — 1 exons

Exon	Start	End
ENSE00002733597	15251627	15251696

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 98.28.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.28	gold quality
skeletal muscle tissue	UBERON:0001134	89.03	gold quality
blood	UBERON:0000178	81.76	gold quality
placenta	UBERON:0001987	79.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.33	gold quality
apex of heart	UBERON:0002098	75.73	gold quality
muscle of leg	UBERON:0001383	75.23	gold quality
calcaneal tendon	UBERON:0003701	75.22	gold quality
gastrocnemius	UBERON:0001388	75.06	gold quality
tibial nerve	UBERON:0001323	72.65	gold quality
gall bladder	UBERON:0002110	71.35	gold quality
heart left ventricle	UBERON:0002084	70.86	gold quality
urinary bladder	UBERON:0001255	70.11	gold quality
heart	UBERON:0000948	70.10	gold quality
body of pancreas	UBERON:0001150	70.06	gold quality
lung	UBERON:0002048	69.83	gold quality
Ammon’s horn	UBERON:0001954	69.72	gold quality
right atrium auricular region	UBERON:0006631	68.95	gold quality
body of stomach	UBERON:0001161	68.65	gold quality
minor salivary gland	UBERON:0001830	68.64	gold quality
endometrium	UBERON:0001295	68.54	gold quality
tibial artery	UBERON:0007610	68.50	gold quality
stomach	UBERON:0000945	68.42	gold quality
left adrenal gland cortex	UBERON:0035825	68.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.93	gold quality
left adrenal gland	UBERON:0001234	67.56	gold quality
thoracic mammary gland	UBERON:0005200	67.55	gold quality
right coronary artery	UBERON:0001625	67.45	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• loss of miR-4731 expression in stage IV patient tumors supports melanoma growth by, in part, reducing its regulatory control of SSX expression levels (PMID:27331623)
• Downregulation of FLVCR1-AS1 inhibited proliferation, migration and invasion of glioma cells. FLVCR1-AS1 directly targeted miR-4731-5p/E2F2 axis. (PMID:31699367)
• MicroRNA-4731-5p delivered by AD-mesenchymal stem cells induces cell cycle arrest and apoptosis in glioblastoma. (PMID:31957033)
• Preliminary study on the mechanism of long noncoding RNA SENCR regulating the proliferation and migration of vascular smooth muscle cells. (PMID:32401347)
• Circular RNA Eps15-homology domain-containing protein 2 induce resistance of renal cell carcinoma to sunitinib via microRNA-4731-5p/ABCF2 axis. (PMID:35412955)
• LINC01857 promotes the proliferation, migration, and invasion of gastric cancer cells via regulating miR-4731-5p/HOXC6. (PMID:35468304)
• A novel circ_0018553 protects against angiotensin-induced cardiac hypertrophy in cardiomyocytes by modulating the miR-4731/SIRT2 signaling pathway. (PMID:36474029)
• Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in ligamentum flavum hypertrophy. (PMID:37014317)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.