MIR4732

Summary

MIR4732 (microRNA 4732, HGNC:41639) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616385 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41639
Approved symbol	MIR4732
Name	microRNA 4732
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4732
Ensembl gene	ENSG00000284085
Ensembl biotype	miRNA
Entrez	100616385
RNAcentral	URS000075B046 — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581873

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581873 — 1 exons

Exon	Start	End
ENSE00002727850	28861655	28861730

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 62.17.

Top tissues by expression

1 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of abdomen	UBERON:0001416	62.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• The results suggested that miR-4732-5p may serve as a tumor suppressor in the initiation of breast cancer, but as a tumor promoter in breast cancer progression by targeting TSPAN13. (PMID:30701690)
• Plasma-derived exosomal miR-4732-5p is a promising noninvasive diagnostic biomarker for epithelial ovarian cancer. (PMID:33910598)
• Can miRNA Indicate Risk of Illness after Continuous Exposure to M. tuberculosis? (PMID:33916069)
• MicroRNA-4732 is downregulated in non-small cell lung cancer and inhibits tumor cell proliferation, migration, and invasion. (PMID:34758406)
• The miR-4732-5p/XPR1 axis suppresses the invasion, metastasis, and epithelial-mesenchymal transition of lung adenocarcinoma via the PI3K/Akt/GSK3beta/Snail pathway. (PMID:35388387)
• miR-4732-3p prevents lung cancer progression via inhibition of the TBX15/TNFSF11 axis. (PMID:37125501)
• Tumor-suppressive miR-4732-3p is sorted into fucosylated exosome by hnRNPK to avoid the inhibition of lung cancer progression. (PMID:38654325)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.