MIR4733

Summary

MIR4733 (microRNA 4733, HGNC:41638) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616266 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41638
Approved symbol	MIR4733
Name	microRNA 4733
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4733
Ensembl gene	ENSG00000265444
Ensembl biotype	miRNA
Entrez	100616266
RNAcentral	URS0000759B05 — ncRNA, 76 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578268

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578268 — 1 exons

Exon	Start	End
ENSE00002691919	31094350	31094425

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 98.32.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.32	gold quality
calcaneal tendon	UBERON:0003701	85.18	gold quality
adrenal tissue	UBERON:0018303	79.10	gold quality
muscle of leg	UBERON:0001383	77.47	gold quality
endometrium	UBERON:0001295	75.16	gold quality
blood	UBERON:0000178	74.78	gold quality
heart left ventricle	UBERON:0002084	72.35	gold quality
adult mammalian kidney	UBERON:0000082	70.37	gold quality
islet of Langerhans	UBERON:0000006	70.14	gold quality
omental fat pad	UBERON:0010414	69.97	gold quality
tibial artery	UBERON:0007610	69.63	gold quality
heart	UBERON:0000948	69.40	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.57	gold quality
liver	UBERON:0002107	68.52	gold quality
urinary bladder	UBERON:0001255	68.03	gold quality
gastrocnemius	UBERON:0001388	67.77	gold quality
body of pancreas	UBERON:0001150	67.72	gold quality
right atrium auricular region	UBERON:0006631	67.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.92	gold quality
lung	UBERON:0002048	66.83	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.73	gold quality
nucleus accumbens	UBERON:0001882	66.43	gold quality
prostate gland	UBERON:0002367	66.00	gold quality
right lobe of thyroid gland	UBERON:0001119	65.94	gold quality
right uterine tube	UBERON:0001302	65.22	gold quality
left coronary artery	UBERON:0001626	65.02	gold quality
cerebral cortex	UBERON:0000956	64.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.71	gold quality
ovary	UBERON:0000992	64.53	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-4733-5p promotes gallbladder carcinoma progression via directly targeting kruppel like factor 7. (PMID:35443866)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.