MIR4734

Summary

MIR4734 (microRNA 4734, HGNC:41572) is a microRNA gene on chromosome 17q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616203 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41572
Approved symbol	MIR4734
Name	microRNA 4734
Location	17q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4734
Ensembl gene	ENSG00000275238
Ensembl biotype	miRNA
Entrez	100616203
RNAcentral	URS000075AF55 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612893

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612893 — 1 exons

Exon	Start	End
ENSE00003716892	38702262	38702331

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 81.35.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	81.35	gold quality
monocyte	CL:0000576	76.43	gold quality
blood	UBERON:0000178	75.61	gold quality
gastrocnemius	UBERON:0001388	74.78	gold quality
adult mammalian kidney	UBERON:0000082	72.65	gold quality
heart left ventricle	UBERON:0002084	71.53	gold quality
right lobe of liver	UBERON:0001114	70.64	gold quality
stomach	UBERON:0000945	70.05	gold quality
heart	UBERON:0000948	69.80	gold quality
right atrium auricular region	UBERON:0006631	69.57	gold quality
liver	UBERON:0002107	68.87	gold quality
left coronary artery	UBERON:0001626	68.81	gold quality
body of stomach	UBERON:0001161	68.48	gold quality
caudate nucleus	UBERON:0001873	67.98	gold quality
left adrenal gland cortex	UBERON:0035825	67.92	gold quality
left adrenal gland	UBERON:0001234	67.86	gold quality
omental fat pad	UBERON:0010414	67.25	gold quality
lung	UBERON:0002048	67.22	gold quality
tibial artery	UBERON:0007610	66.50	gold quality
substantia nigra	UBERON:0002038	66.42	gold quality
colon	UBERON:0001155	66.34	gold quality
right frontal lobe	UBERON:0002810	66.00	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.88	gold quality
endometrium	UBERON:0001295	65.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.62	gold quality
skin of abdomen	UBERON:0001416	65.48	gold quality
ascending aorta	UBERON:0001496	65.34	gold quality
skin of leg	UBERON:0001511	65.24	gold quality
esophagus mucosa	UBERON:0002469	65.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-4734 conditionally suppresses ER stress-associated proinflammatory responses. (PMID:36445168)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.