MIR4735

Summary

MIR4735 (microRNA 4735, HGNC:41888) is a microRNA gene on chromosome 1q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616363 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41888
Approved symbol	MIR4735
Name	microRNA 4735
Location	1q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4735
Ensembl gene	ENSG00000265986
Ensembl biotype	miRNA
Entrez	100616363
RNAcentral	URS000075B068 — ncRNA, 69 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580028

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580028 — 1 exons

Exon	Start	End
ENSE00002712227	196582413	196582481

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 81.97.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	81.97	gold quality
adult mammalian kidney	UBERON:0000082	80.00	gold quality
kidney	UBERON:0002113	79.81	gold quality
liver	UBERON:0002107	79.43	gold quality
adrenal tissue	UBERON:0018303	77.40	gold quality
stomach	UBERON:0000945	74.12	gold quality
intestine	UBERON:0000160	74.00	gold quality
heart	UBERON:0000948	73.35	gold quality
lung	UBERON:0002048	71.83	gold quality
gastrocnemius	UBERON:0001388	71.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.59	gold quality
body of stomach	UBERON:0001161	69.89	gold quality
apex of heart	UBERON:0002098	69.64	gold quality
minor salivary gland	UBERON:0001830	69.24	gold quality
tibial artery	UBERON:0007610	68.99	gold quality
colon	UBERON:0001155	68.88	gold quality
skin of leg	UBERON:0001511	68.20	gold quality
right atrium auricular region	UBERON:0006631	67.91	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.87	gold quality
right lobe of thyroid gland	UBERON:0001119	66.81	gold quality
putamen	UBERON:0001874	66.75	gold quality
esophagus mucosa	UBERON:0002469	66.19	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.10	gold quality
substantia nigra	UBERON:0002038	65.97	gold quality
left ovary	UBERON:0002119	65.18	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.13	gold quality
myometrium	UBERON:0001296	64.87	gold quality
tibial nerve	UBERON:0001323	64.70	gold quality
omental fat pad	UBERON:0010414	63.44	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Low miR4735 expression is associated with bladder cancer. (PMID:30404578)
• FBXL3 was regulated by miR-4735-3p and suppressed cell proliferation and invasion in non-small cell lung cancer. (PMID:30594330)
• miR-4735-3p regulates phenotypic modulation of vascular smooth muscle cells by targeting HIF-1-mediated autophagy in intracranial aneurysm. (PMID:31498485)
• MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1. (PMID:35646516)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.