MIR4736

Summary

MIR4736 (microRNA 4736, HGNC:41804) is a microRNA gene on chromosome 17q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616220 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41804
Approved symbol	MIR4736
Name	microRNA 4736
Location	17q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4736
Ensembl gene	ENSG00000264399
Ensembl biotype	miRNA
Entrez	100616220
RNAcentral	URS000075E7FB — ncRNA, 47 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581591

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581591 — 1 exons

Exon	Start	End
ENSE00002722555	58335976	58336022

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 97.64.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4275 / max 41.5373, expressed in 162 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
167243	0.2195	103
167244	0.2080	94

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.64	gold quality
adrenal tissue	UBERON:0018303	86.87	gold quality
calcaneal tendon	UBERON:0003701	84.55	gold quality
granulocyte	CL:0000094	83.10	gold quality
endometrium	UBERON:0001295	81.44	gold quality
blood	UBERON:0000178	79.98	gold quality
bone marrow	UBERON:0002371	79.98	gold quality
heart left ventricle	UBERON:0002084	76.44	gold quality
lymph node	UBERON:0000029	76.36	gold quality
left adrenal gland	UBERON:0001234	76.25	gold quality
monocyte	CL:0000576	76.00	gold quality
gastrocnemius	UBERON:0001388	75.97	gold quality
heart	UBERON:0000948	75.92	gold quality
right lobe of liver	UBERON:0001114	75.52	gold quality
kidney	UBERON:0002113	74.50	gold quality
tibial nerve	UBERON:0001323	74.28	gold quality
islet of Langerhans	UBERON:0000006	74.22	gold quality
substantia nigra	UBERON:0002038	74.06	gold quality
right atrium auricular region	UBERON:0006631	73.33	gold quality
lung	UBERON:0002048	72.89	gold quality
stomach	UBERON:0000945	71.93	gold quality
Ammon’s horn	UBERON:0001954	71.23	gold quality
esophagus mucosa	UBERON:0002469	71.07	gold quality
prostate gland	UBERON:0002367	70.79	gold quality
thoracic mammary gland	UBERON:0005200	70.73	gold quality
ascending aorta	UBERON:0001496	70.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.07	gold quality
body of stomach	UBERON:0001161	69.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.55

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.