MIR4737

Summary

MIR4737 (microRNA 4737, HGNC:41669) is a microRNA gene on chromosome 17q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616210 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41669
Approved symbol	MIR4737
Name	microRNA 4737
Location	17q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4737
Ensembl gene	ENSG00000264049
Ensembl biotype	miRNA
Entrez	100616210
RNAcentral	URS000075DACB — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583979

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583979 — 1 exons

Exon	Start	End
ENSE00002705052	60043025	60043105

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 81.55.

Top tissues by expression

42 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	81.55	gold quality
endometrium	UBERON:0001295	80.57	gold quality
right lobe of thyroid gland	UBERON:0001119	78.48	gold quality
frontal cortex	UBERON:0001870	75.35	gold quality
prostate gland	UBERON:0002367	74.79	gold quality
spleen	UBERON:0002106	74.43	gold quality
upper lobe of left lung	UBERON:0008952	71.88	gold quality
blood	UBERON:0000178	69.80	gold quality
nucleus accumbens	UBERON:0001882	69.01	gold quality
muscle of leg	UBERON:0001383	67.47	gold quality
left lobe of thyroid gland	UBERON:0001120	66.46	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.01	gold quality
gastrocnemius	UBERON:0001388	65.70	gold quality
stomach	UBERON:0000945	63.94	gold quality
intestine	UBERON:0000160	63.61	gold quality
body of stomach	UBERON:0001161	63.45	gold quality
skin of leg	UBERON:0001511	62.94	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.62	gold quality
brain	UBERON:0000955	61.54	gold quality
islet of Langerhans	UBERON:0000006	61.33	gold quality
liver	UBERON:0002107	60.24	silver quality
amygdala	UBERON:0001876	60.18	gold quality
zone of skin	UBERON:0000014	59.38	gold quality
tibial artery	UBERON:0007610	59.20	gold quality
lung	UBERON:0002048	57.67	gold quality
heart	UBERON:0000948	56.81	gold quality
caudate nucleus	UBERON:0001873	56.76	gold quality
ascending aorta	UBERON:0001496	56.59	gold quality
left coronary artery	UBERON:0001626	56.49	gold quality
body of pancreas	UBERON:0001150	56.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.44

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.