MIR4738

Summary

MIR4738 (microRNA 4738, HGNC:41679) is a microRNA gene on chromosome 17q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616282 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41679
Approved symbol	MIR4738
Name	microRNA 4738
Location	17q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4738
Ensembl gene	ENSG00000283853
Ensembl biotype	miRNA
Entrez	100616282
RNAcentral	URS000075993E — miRNA, 87 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579134

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579134 — 1 exons

Exon	Start	End
ENSE00002696947	75784521	75784607

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 93.67.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.67	gold quality
tibial artery	UBERON:0007610	66.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.88	gold quality
esophagus mucosa	UBERON:0002469	62.98	gold quality
skin of abdomen	UBERON:0001416	62.30	gold quality
blood	UBERON:0000178	61.78	gold quality
nucleus accumbens	UBERON:0001882	60.22	gold quality
spleen	UBERON:0002106	54.27	gold quality
lung	UBERON:0002048	49.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Exosome miR-4738-3p-mediated regulation of COL1A2 through the NF-kappaB and inflammation signaling pathway alleviates osteoarthritis low-grade inflammation symptoms. (PMID:38059912)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.