MIR4739

Summary

MIR4739 (microRNA 4739, HGNC:41801) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616170 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41801
Approved symbol	MIR4739
Name	microRNA 4739
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4739
Ensembl gene	ENSG00000266665
Ensembl biotype	miRNA
Entrez	100616170
RNAcentral	URS0000759B47 — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577633

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577633 — 1 exons

Exon	Start	End
ENSE00002712112	79707176	79707249

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 82.23.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.23	gold quality
bone marrow	UBERON:0002371	80.67	gold quality
monocyte	CL:0000576	76.72	gold quality
blood	UBERON:0000178	74.88	gold quality
endometrium	UBERON:0001295	71.70	gold quality
body of pancreas	UBERON:0001150	69.58	gold quality
tibial artery	UBERON:0007610	68.59	gold quality
liver	UBERON:0002107	68.57	gold quality
body of stomach	UBERON:0001161	68.13	gold quality
right lobe of liver	UBERON:0001114	67.74	gold quality
adult mammalian kidney	UBERON:0000082	66.98	gold quality
pituitary gland	UBERON:0000007	66.37	gold quality
transverse colon	UBERON:0001157	65.89	gold quality
spleen	UBERON:0002106	64.68	gold quality
caudate nucleus	UBERON:0001873	64.54	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.97	gold quality
omental fat pad	UBERON:0010414	63.81	gold quality
cerebellar hemisphere	UBERON:0002245	63.78	gold quality
tibial nerve	UBERON:0001323	63.15	gold quality
multicellular organism	UBERON:0000468	62.75	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.34	gold quality
nucleus accumbens	UBERON:0001882	61.72	gold quality
esophagus mucosa	UBERON:0002469	61.66	gold quality
putamen	UBERON:0001874	61.45	gold quality
prostate gland	UBERON:0002367	61.23	gold quality
minor salivary gland	UBERON:0001830	61.17	gold quality
urinary bladder	UBERON:0001255	60.52	gold quality
vagina	UBERON:0000996	57.04	gold quality
skin of leg	UBERON:0001511	56.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• The role of hsa-miR-4739 in regulating LRP3 expression was confirmed by qRT-PCR and western blotting, which showed suppression of LRP3 mRNA and protein expression, respectively, in hsa-miR-4739 transfected imCL1 cells (PMID:28340487)
• miRNA-4739 is implicated as a novel diagnostic marker and a potential therapeutic target for Critical limb ischemia in diabetes. (PMID:30539011)
• High levels of miR-4739 and low levels of bone morphogenetic protein 7 associated with pleural fibrosis in patients and targeted and down-regulated BMP-7 which further resulted in unbalance between Smad1/5/9 and Smad2/3 signaling. (PMID:30850350)
• ZEB1 activated-VPS9D1-AS1 promotes the tumorigenesis and progression of prostate cancer by sponging miR-4739 to upregulate MEF2D. (PMID:31918265)
• Circular RNA Hsa_circ_0006766 targets microRNA miR-4739 to regulate osteogenic differentiation of human bone marrow mesenchymal stem cells. (PMID:34524066)
• The miR-4739/DLX3 Axis Modulates Bone Marrow-Derived Mesenchymal Stem Cell (BMSC) Osteogenesis Affecting Osteoporosis Progression. (PMID:34925225)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.