MIR4740

Summary

MIR4740 (microRNA 4740, HGNC:41711) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616294 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41711
Approved symbol	MIR4740
Name	microRNA 4740
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4740
Ensembl gene	ENSG00000266392
Ensembl biotype	miRNA
Entrez	100616294
RNAcentral	URS000075B324 — miRNA, 63 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584184

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584184 — 1 exons

Exon	Start	End
ENSE00002732732	81400716	81400778

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 95.86.

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.86	gold quality
cerebellar hemisphere	UBERON:0002245	95.11	gold quality
duodenum	UBERON:0002114	90.94	gold quality
Brodmann (1909) area 9	UBERON:0013540	87.40	gold quality
right adrenal gland cortex	UBERON:0035827	87.13	gold quality
skeletal muscle tissue	UBERON:0001134	86.50	gold quality
putamen	UBERON:0001874	86.40	gold quality
right uterine tube	UBERON:0001302	86.39	gold quality
left adrenal gland cortex	UBERON:0035825	86.11	gold quality
left adrenal gland	UBERON:0001234	86.00	gold quality
fundus of stomach	UBERON:0001160	85.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	85.71	gold quality
right adrenal gland	UBERON:0001233	85.70	gold quality
lower esophagus	UBERON:0013473	85.70	gold quality
ascending aorta	UBERON:0001496	85.62	gold quality
adrenal gland	UBERON:0002369	85.59	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.48	gold quality
thoracic aorta	UBERON:0001515	85.43	gold quality
brain	UBERON:0000955	85.35	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	84.75	gold quality
caudate nucleus	UBERON:0001873	84.74	gold quality
nucleus accumbens	UBERON:0001882	84.61	gold quality
cerebral cortex	UBERON:0000956	84.52	gold quality
right frontal lobe	UBERON:0002810	84.45	gold quality
frontal cortex	UBERON:0001870	84.35	gold quality
endocervix	UBERON:0000458	84.19	gold quality
monocyte	CL:0000576	84.10	gold quality
Ammon’s horn	UBERON:0001954	83.92	gold quality
leukocyte	CL:0000738	83.71	gold quality
myometrium	UBERON:0001296	83.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.