MIR4741

Summary

MIR4741 (microRNA 4741, HGNC:41661) is a microRNA gene on chromosome 18q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616139 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41661
Approved symbol	MIR4741
Name	microRNA 4741
Location	18q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4741
Ensembl gene	ENSG00000284331
Ensembl biotype	miRNA
Entrez	100616139
RNAcentral	URS000075C7BD — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579822

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579822 — 1 exons

Exon	Start	End
ENSE00002721639	22933349	22933438

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 69.94.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.9835 / max 183.0428, expressed in 1654 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
169652	8.9835	1654

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	69.94	gold quality
right atrium auricular region	UBERON:0006631	69.70	gold quality
body of stomach	UBERON:0001161	65.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.60	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.51	gold quality
gastrocnemius	UBERON:0001388	63.05	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.94	gold quality
heart left ventricle	UBERON:0002084	53.10	gold quality
right frontal lobe	UBERON:0002810	51.89	gold quality
spleen	UBERON:0002106	50.49	gold quality
transverse colon	UBERON:0001157	47.51	silver quality
tibial artery	UBERON:0007610	46.18	silver quality
left adrenal gland cortex	UBERON:0035825	46.09	gold quality
tibial nerve	UBERON:0001323	45.43	gold quality
skin of leg	UBERON:0001511	37.63	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.