MIR4742

Summary

MIR4742 (microRNA 4742, HGNC:41565) is a microRNA gene on chromosome 1q42.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616468 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41565
Approved symbol	MIR4742
Name	microRNA 4742
Location	1q42.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4742
Ensembl gene	ENSG00000266618
Ensembl biotype	miRNA
Entrez	100616468
RNAcentral	URS000075DC2B — miRNA, 85 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581069

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581069 — 1 exons

Exon	Start	End
ENSE00002698249	224398227	224398311

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 92.97.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	92.97	gold quality
sural nerve	UBERON:0015488	91.72	gold quality
calcaneal tendon	UBERON:0003701	85.47	gold quality
adrenal tissue	UBERON:0018303	85.14	gold quality
lower esophagus mucosa	UBERON:0035834	84.27	gold quality
blood	UBERON:0000178	82.68	gold quality
duodenum	UBERON:0002114	81.55	gold quality
endometrium	UBERON:0001295	80.67	gold quality
monocyte	CL:0000576	78.67	gold quality
skin of leg	UBERON:0001511	78.13	gold quality
zone of skin	UBERON:0000014	77.71	gold quality
corpus callosum	UBERON:0002336	77.65	gold quality
skin of abdomen	UBERON:0001416	77.13	gold quality
vagina	UBERON:0000996	77.02	gold quality
kidney	UBERON:0002113	76.50	gold quality
muscle of leg	UBERON:0001383	76.28	gold quality
ectocervix	UBERON:0012249	75.89	gold quality
gastrocnemius	UBERON:0001388	75.41	gold quality
islet of Langerhans	UBERON:0000006	75.20	gold quality
right atrium auricular region	UBERON:0006631	74.54	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.29	gold quality
liver	UBERON:0002107	74.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.67	gold quality
right adrenal gland cortex	UBERON:0035827	73.67	gold quality
lung	UBERON:0002048	73.64	gold quality
stomach	UBERON:0000945	73.42	gold quality
adipose tissue	UBERON:0001013	73.26	gold quality
adult mammalian kidney	UBERON:0000082	73.04	gold quality
heart	UBERON:0000948	72.97	gold quality
urinary bladder	UBERON:0001255	72.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC01140 inhibits nonsmall cell lung cancer progression and cisplatin resistance through the miR-4742-5p/TACC1 axis. (PMID:35307914)
• miR-4742-5p promotes invasiveness of gastric cancer via targeting Rab43: An in vitro study. (PMID:35597125)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.