MIR4743

Summary

MIR4743 (microRNA 4743, HGNC:41894) is a microRNA gene on chromosome 18q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616366 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41894
Approved symbol	MIR4743
Name	microRNA 4743
Location	18q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4743
Ensembl gene	ENSG00000266276
Ensembl biotype	miRNA
Entrez	100616366
RNAcentral	URS000075A2DF — ncRNA, 69 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584576

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584576 — 1 exons

Exon	Start	End
ENSE00002717859	48670600	48670668

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 80.45.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.45	gold quality
blood	UBERON:0000178	78.97	gold quality
gastrocnemius	UBERON:0001388	72.11	gold quality
stomach	UBERON:0000945	70.88	gold quality
body of stomach	UBERON:0001161	69.02	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.97	gold quality
tibial artery	UBERON:0007610	68.90	gold quality
esophagus mucosa	UBERON:0002469	68.60	gold quality
lung	UBERON:0002048	68.55	gold quality
thoracic aorta	UBERON:0001515	67.89	gold quality
ascending aorta	UBERON:0001496	67.80	gold quality
body of pancreas	UBERON:0001150	67.43	gold quality
heart	UBERON:0000948	67.37	gold quality
transverse colon	UBERON:0001157	66.91	gold quality
right atrium auricular region	UBERON:0006631	66.76	gold quality
lower esophagus	UBERON:0013473	66.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.32	gold quality
amygdala	UBERON:0001876	66.28	gold quality
nucleus accumbens	UBERON:0001882	65.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.81	gold quality
putamen	UBERON:0001874	65.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.45	gold quality
body of uterus	UBERON:0009853	65.34	gold quality
ovary	UBERON:0000992	65.20	gold quality
zone of skin	UBERON:0000014	65.12	gold quality
skin of leg	UBERON:0001511	64.92	gold quality
liver	UBERON:0002107	64.56	gold quality
Ammon’s horn	UBERON:0001954	64.49	gold quality
endometrium	UBERON:0001295	64.09	gold quality
caudate nucleus	UBERON:0001873	63.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• This study demonstrated that MIR4743 in patient with major depression disorder was up regulation in peripheral blood mononuclear cells. (PMID:25201637)
• Identification of plasma miR-4505, miR-4743-5p and miR-4750-3p as novel diagnostic biomarkers for coronary artery disease in patients with type 2 diabetes mellitus: a case-control study. (PMID:39080630)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.