MIR4744

Summary

MIR4744 (microRNA 4744, HGNC:41866) is a microRNA gene on chromosome 18q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616420 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41866
Approved symbol	MIR4744
Name	microRNA 4744
Location	18q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4744
Ensembl gene	ENSG00000263849
Ensembl biotype	miRNA
Entrez	100616420
RNAcentral	URS000075DDA1 — ncRNA, 82 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581563

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581563 — 1 exons

Exon	Start	End
ENSE00002685604	49049687	49049768

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 79.10.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	79.10	gold quality
endometrium	UBERON:0001295	78.43	gold quality
bone marrow	UBERON:0002371	77.52	gold quality
adrenal tissue	UBERON:0018303	77.40	gold quality
blood	UBERON:0000178	77.05	gold quality
monocyte	CL:0000576	74.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.75	gold quality
fundus of stomach	UBERON:0001160	73.06	gold quality
islet of Langerhans	UBERON:0000006	72.68	gold quality
muscle of leg	UBERON:0001383	72.42	gold quality
gastrocnemius	UBERON:0001388	72.13	gold quality
body of pancreas	UBERON:0001150	71.74	gold quality
heart left ventricle	UBERON:0002084	71.29	gold quality
stomach	UBERON:0000945	70.64	gold quality
liver	UBERON:0002107	70.50	gold quality
heart	UBERON:0000948	69.84	gold quality
body of stomach	UBERON:0001161	69.60	gold quality
left coronary artery	UBERON:0001626	69.24	gold quality
kidney	UBERON:0002113	69.03	gold quality
substantia nigra	UBERON:0002038	68.85	gold quality
adrenal gland	UBERON:0002369	68.46	gold quality
mucosa of stomach	UBERON:0001199	68.42	gold quality
right adrenal gland	UBERON:0001233	68.32	gold quality
popliteal artery	UBERON:0002250	67.99	gold quality
tibial artery	UBERON:0007610	67.94	gold quality
myometrium	UBERON:0001296	67.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.80	gold quality
left adrenal gland cortex	UBERON:0035825	67.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.61	gold quality
esophagus	UBERON:0001043	67.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• RIOK2 is negatively regulated by miR-4744 and promotes glioma cell migration/invasion through epithelial-mesenchymal transition. (PMID:32125767)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.