MIR4745

Summary

MIR4745 (microRNA 4745, HGNC:41868) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616459 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41868
Approved symbol	MIR4745
Name	microRNA 4745
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4745
Ensembl gene	ENSG00000284361
Ensembl biotype	miRNA
Entrez	100616459
RNAcentral	URS000075C987 — miRNA, 62 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577608

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577608 — 1 exons

Exon	Start	End
ENSE00002712451	804940	805001

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 74.29.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	74.29	gold quality
body of stomach	UBERON:0001161	69.23	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.13	gold quality
blood	UBERON:0000178	66.60	gold quality
ectocervix	UBERON:0012249	65.78	gold quality
ascending aorta	UBERON:0001496	64.41	gold quality
upper lobe of left lung	UBERON:0008952	61.98	gold quality
omental fat pad	UBERON:0010414	61.65	gold quality
metanephros cortex	UBERON:0010533	60.29	gold quality
skin of leg	UBERON:0001511	59.95	gold quality
left ovary	UBERON:0002119	59.17	gold quality
tibial nerve	UBERON:0001323	56.56	gold quality
pituitary gland	UBERON:0000007	56.09	gold quality
esophagus mucosa	UBERON:0002469	51.60	gold quality
transverse colon	UBERON:0001157	50.82	gold quality
adrenal gland	UBERON:0002369	44.08	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.