MIR4746

Summary

MIR4746 (microRNA 4746, HGNC:41904) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616371 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41904
Approved symbol	MIR4746
Name	microRNA 4746
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4746
Ensembl gene	ENSG00000266437
Ensembl biotype	miRNA
Entrez	100616371
RNAcentral	URS000075E8F3 — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579802

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579802 — 1 exons

Exon	Start	End
ENSE00002715458	4445978	4446048

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 80.12.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	80.12	gold quality
body of pancreas	UBERON:0001150	74.05	gold quality
blood	UBERON:0000178	66.96	gold quality
body of stomach	UBERON:0001161	65.06	gold quality
right lobe of thyroid gland	UBERON:0001119	65.04	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.11	gold quality
heart	UBERON:0000948	63.03	gold quality
heart left ventricle	UBERON:0002084	62.97	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.78	gold quality
gastrocnemius	UBERON:0001388	61.69	gold quality
hypothalamus	UBERON:0001898	61.23	gold quality
putamen	UBERON:0001874	60.69	gold quality
esophagus mucosa	UBERON:0002469	60.62	gold quality
transverse colon	UBERON:0001157	60.56	gold quality
omental fat pad	UBERON:0010414	59.19	gold quality
right frontal lobe	UBERON:0002810	58.63	gold quality
left adrenal gland cortex	UBERON:0035825	56.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	56.38	gold quality
tibial artery	UBERON:0007610	56.21	gold quality
minor salivary gland	UBERON:0001830	53.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	53.65	gold quality
skin of leg	UBERON:0001511	53.35	gold quality
small intestine Peyer’s patch	UBERON:0003454	53.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	52.15	gold quality
caudate nucleus	UBERON:0001873	50.38	gold quality
prostate gland	UBERON:0002367	49.42	gold quality
tibial nerve	UBERON:0001323	48.45	gold quality
ascending aorta	UBERON:0001496	47.77	gold quality
skin of abdomen	UBERON:0001416	46.96	gold quality
substantia nigra	UBERON:0002038	46.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Mir-4746 inhibits the proliferation of colorectal cancer cells in vitro and in vivo by targeting CCND1. (PMID:35085892)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.