MIR4747

Summary

MIR4747 (microRNA 4747, HGNC:41827) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616337 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41827
Approved symbol	MIR4747
Name	microRNA 4747
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4747
Ensembl gene	ENSG00000263409
Ensembl biotype	miRNA
Entrez	100616337
RNAcentral	URS000075F0D8 — miRNA, 54 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584057

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584057 — 1 exons

Exon	Start	End
ENSE00002716702	4932687	4932740

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 80.19.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	80.19	gold quality
bone marrow	UBERON:0002371	78.19	gold quality
adrenal tissue	UBERON:0018303	75.86	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.23	gold quality
gastrocnemius	UBERON:0001388	72.63	gold quality
right testis	UBERON:0004534	68.84	gold quality
anterior cingulate cortex	UBERON:0009835	68.25	gold quality
right adrenal gland	UBERON:0001233	67.71	gold quality
vagina	UBERON:0000996	67.67	gold quality
skin of leg	UBERON:0001511	67.66	gold quality
thoracic mammary gland	UBERON:0005200	67.17	gold quality
right frontal lobe	UBERON:0002810	67.09	gold quality
esophagus mucosa	UBERON:0002469	66.74	gold quality
putamen	UBERON:0001874	66.54	gold quality
hypothalamus	UBERON:0001898	65.47	gold quality
upper lobe of left lung	UBERON:0008952	65.46	gold quality
skin of abdomen	UBERON:0001416	65.33	gold quality
tibial nerve	UBERON:0001323	64.86	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.32	gold quality
endocervix	UBERON:0000458	62.47	gold quality
amygdala	UBERON:0001876	61.01	gold quality
left testis	UBERON:0004533	47.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.