MIR4748

Summary

MIR4748 (microRNA 4748, HGNC:41557) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616425 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41557
Approved symbol	MIR4748
Name	microRNA 4748
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4748
Ensembl gene	ENSG00000265879
Ensembl biotype	miRNA
Entrez	100616425
RNAcentral	URS000075DDD6 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578076

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578076 — 1 exons

Exon	Start	End
ENSE00002694874	10780254	10780335

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 80.60.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.60	gold quality
blood	UBERON:0000178	78.98	gold quality
monocyte	CL:0000576	73.72	gold quality
muscle of leg	UBERON:0001383	73.58	gold quality
kidney	UBERON:0002113	73.26	gold quality
heart left ventricle	UBERON:0002084	72.50	gold quality
calcaneal tendon	UBERON:0003701	72.43	gold quality
heart	UBERON:0000948	72.18	gold quality
gastrocnemius	UBERON:0001388	72.18	gold quality
stomach	UBERON:0000945	71.43	gold quality
endometrium	UBERON:0001295	69.77	gold quality
adrenal gland	UBERON:0002369	69.19	gold quality
prefrontal cortex	UBERON:0000451	68.47	gold quality
body of pancreas	UBERON:0001150	68.13	gold quality
right atrium auricular region	UBERON:0006631	67.26	gold quality
urinary bladder	UBERON:0001255	66.75	gold quality
esophagus mucosa	UBERON:0002469	66.61	gold quality
adult mammalian kidney	UBERON:0000082	66.58	gold quality
thoracic aorta	UBERON:0001515	66.47	gold quality
left uterine tube	UBERON:0001303	66.46	gold quality
myometrium	UBERON:0001296	66.37	gold quality
lung	UBERON:0002048	66.24	gold quality
transverse colon	UBERON:0001157	66.16	gold quality
ascending aorta	UBERON:0001496	66.12	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.08	gold quality
right adrenal gland cortex	UBERON:0035827	66.04	gold quality
intestine	UBERON:0000160	65.88	gold quality
body of stomach	UBERON:0001161	65.50	gold quality
tibial artery	UBERON:0007610	65.39	gold quality
colon	UBERON:0001155	65.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.