MIR4749

Summary

MIR4749 (microRNA 4749, HGNC:41760) is a microRNA gene on chromosome 19q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616313 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41760
Approved symbol	MIR4749
Name	microRNA 4749
Location	19q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4749
Ensembl gene	ENSG00000265954
Ensembl biotype	miRNA
Entrez	100616313
RNAcentral	URS000075D57A — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578197

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578197 — 1 exons

Exon	Start	End
ENSE00002711389	49854591	49854651

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 85.25.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	85.25	gold quality
lymph node	UBERON:0000029	83.16	gold quality
blood	UBERON:0000178	76.91	gold quality
mucosa of stomach	UBERON:0001199	75.16	gold quality
muscle of leg	UBERON:0001383	75.10	gold quality
monocyte	CL:0000576	74.37	gold quality
gastrocnemius	UBERON:0001388	74.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.10	gold quality
right lobe of liver	UBERON:0001114	71.79	gold quality
right adrenal gland	UBERON:0001233	70.81	gold quality
endocervix	UBERON:0000458	70.63	gold quality
tibial artery	UBERON:0007610	70.35	gold quality
body of stomach	UBERON:0001161	70.01	gold quality
body of pancreas	UBERON:0001150	69.64	gold quality
heart left ventricle	UBERON:0002084	69.64	gold quality
Ammon’s horn	UBERON:0001954	69.32	gold quality
fundus of stomach	UBERON:0001160	69.03	gold quality
left coronary artery	UBERON:0001626	68.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.14	gold quality
descending thoracic aorta	UBERON:0002345	67.86	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.51	gold quality
right atrium auricular region	UBERON:0006631	67.31	gold quality
ascending aorta	UBERON:0001496	66.86	gold quality
colon	UBERON:0001155	66.83	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.70	gold quality
putamen	UBERON:0001874	66.59	gold quality
transverse colon	UBERON:0001157	66.47	gold quality
mucosa of transverse colon	UBERON:0004991	66.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Investigation of a Direct Interaction between miR4749 and the Tumor Suppressor p53 by Fluorescence, FRET and Molecular Modeling. (PMID:32098369)
• Interaction between miR4749 and Human Serum Albumin as Revealed by Fluorescence, FRET, Atomic Force Spectroscopy and Computational Modelling. (PMID:35163220)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.