MIR4750

Summary

MIR4750 (microRNA 4750, HGNC:41765) is a microRNA gene on chromosome 19q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616314 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41765
Approved symbol	MIR4750
Name	microRNA 4750
Location	19q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4750
Ensembl gene	ENSG00000284394
Ensembl biotype	miRNA
Entrez	100616314
RNAcentral	URS000075DADC — miRNA, 56 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584564

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584564 — 1 exons

Exon	Start	End
ENSE00002713790	49888175	49888230

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 74.23.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	74.23	gold quality
cerebral cortex	UBERON:0000956	72.18	gold quality
blood	UBERON:0000178	69.25	gold quality
brain	UBERON:0000955	68.54	gold quality
multicellular organism	UBERON:0000468	63.55	gold quality
right atrium auricular region	UBERON:0006631	63.31	gold quality
heart left ventricle	UBERON:0002084	56.68	gold quality
saliva-secreting gland	UBERON:0001044	53.96	gold quality
amygdala	UBERON:0001876	51.68	gold quality
skin of leg	UBERON:0001511	50.28	gold quality
body of stomach	UBERON:0001161	47.90	gold quality
gastrocnemius	UBERON:0001388	37.25	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Identification of plasma miR-4505, miR-4743-5p and miR-4750-3p as novel diagnostic biomarkers for coronary artery disease in patients with type 2 diabetes mellitus: a case-control study. (PMID:39080630)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.