MIR4752

Summary

MIR4752 (microRNA 4752, HGNC:41803) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616171 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41803
Approved symbol	MIR4752
Name	microRNA 4752
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4752
Ensembl gene	ENSG00000264703
Ensembl biotype	miRNA
Entrez	100616171
RNAcentral	URS000075AB7E — ncRNA, 72 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579672

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579672 — 1 exons

Exon	Start	End
ENSE00002687793	54282109	54282180

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 83.92.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	83.92	gold quality
granulocyte	CL:0000094	80.40	gold quality
monocyte	CL:0000576	79.33	gold quality
lymph node	UBERON:0000029	78.36	gold quality
blood	UBERON:0000178	75.55	gold quality
spleen	UBERON:0002106	75.48	gold quality
urinary bladder	UBERON:0001255	75.11	gold quality
smooth muscle tissue	UBERON:0001135	70.59	gold quality
right adrenal gland	UBERON:0001233	69.89	gold quality
adrenal gland	UBERON:0002369	69.56	gold quality
Ammon’s horn	UBERON:0001954	69.21	gold quality
right adrenal gland cortex	UBERON:0035827	69.09	gold quality
right lobe of liver	UBERON:0001114	69.03	gold quality
tonsil	UBERON:0002372	68.48	gold quality
stomach	UBERON:0000945	68.44	gold quality
rectum	UBERON:0001052	68.39	gold quality
right atrium auricular region	UBERON:0006631	68.10	gold quality
left adrenal gland	UBERON:0001234	67.99	gold quality
left adrenal gland cortex	UBERON:0035825	67.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.51	gold quality
body of stomach	UBERON:0001161	67.36	gold quality
colon	UBERON:0001155	67.21	gold quality
substantia nigra	UBERON:0002038	66.68	gold quality
multicellular organism	UBERON:0000468	66.42	gold quality
lung	UBERON:0002048	66.30	gold quality
transverse colon	UBERON:0001157	66.27	gold quality
omental fat pad	UBERON:0010414	66.15	gold quality
amygdala	UBERON:0001876	66.00	gold quality
ascending aorta	UBERON:0001496	65.60	gold quality
upper lobe of left lung	UBERON:0008952	65.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.