MIR4753

Summary

MIR4753 (microRNA 4753, HGNC:41527) is a microRNA gene on chromosome 1q42.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616224 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41527
Approved symbol	MIR4753
Name	microRNA 4753
Location	1q42.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4753
Ensembl gene	ENSG00000263439
Ensembl biotype	miRNA
Entrez	100616224
RNAcentral	URS000075DF35 — ncRNA, 83 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585119

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585119 — 1 exons

Exon	Start	End
ENSE00002713574	235190034	235190116

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 90.44.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	90.44	gold quality
adrenal tissue	UBERON:0018303	85.41	gold quality
blood	UBERON:0000178	79.02	gold quality
endometrium	UBERON:0001295	77.39	gold quality
anterior cingulate cortex	UBERON:0009835	75.06	gold quality
gastrocnemius	UBERON:0001388	73.94	gold quality
lymph node	UBERON:0000029	73.82	gold quality
monocyte	CL:0000576	71.78	gold quality
heart	UBERON:0000948	71.61	gold quality
lung	UBERON:0002048	71.60	gold quality
left adrenal gland cortex	UBERON:0035825	70.60	gold quality
urinary bladder	UBERON:0001255	70.34	gold quality
stomach	UBERON:0000945	69.67	gold quality
heart left ventricle	UBERON:0002084	69.35	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.14	gold quality
liver	UBERON:0002107	68.83	gold quality
ascending aorta	UBERON:0001496	68.79	gold quality
tibial artery	UBERON:0007610	68.75	gold quality
left adrenal gland	UBERON:0001234	67.85	gold quality
esophagus mucosa	UBERON:0002469	67.20	gold quality
body of pancreas	UBERON:0001150	66.79	gold quality
thoracic mammary gland	UBERON:0005200	66.73	gold quality
minor salivary gland	UBERON:0001830	66.70	gold quality
intestine	UBERON:0000160	66.44	gold quality
right lobe of liver	UBERON:0001114	66.10	gold quality
putamen	UBERON:0001874	65.50	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.24	gold quality
transverse colon	UBERON:0001157	64.86	gold quality
left ovary	UBERON:0002119	64.70	gold quality
skin of leg	UBERON:0001511	64.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.