MIR4755

Summary

MIR4755 (microRNA 4755, HGNC:41815) is a microRNA gene on chromosome 20q11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616434 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41815
Approved symbol	MIR4755
Name	microRNA 4755
Location	20q11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4755
Ensembl gene	ENSG00000264616
Ensembl biotype	miRNA
Entrez	100616434
RNAcentral	URS000075DBCD — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583905

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583905 — 1 exons

Exon	Start	End
ENSE00002734522	34049119	34049190

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 96.79.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.79	gold quality
bone marrow	UBERON:0002371	82.80	gold quality
adrenal tissue	UBERON:0018303	82.38	gold quality
blood	UBERON:0000178	81.19	gold quality
kidney	UBERON:0002113	79.30	gold quality
calcaneal tendon	UBERON:0003701	77.14	gold quality
placenta	UBERON:0001987	76.49	gold quality
stomach	UBERON:0000945	75.46	gold quality
liver	UBERON:0002107	75.09	gold quality
monocyte	CL:0000576	74.96	gold quality
corpus callosum	UBERON:0002336	74.33	gold quality
gastrocnemius	UBERON:0001388	73.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.45	gold quality
lung	UBERON:0002048	72.94	gold quality
heart	UBERON:0000948	71.49	gold quality
tonsil	UBERON:0002372	70.33	gold quality
endometrium	UBERON:0001295	69.86	gold quality
left adrenal gland	UBERON:0001234	69.23	gold quality
body of pancreas	UBERON:0001150	68.78	gold quality
intestine	UBERON:0000160	68.73	gold quality
heart left ventricle	UBERON:0002084	68.56	gold quality
colon	UBERON:0001155	68.45	gold quality
right atrium auricular region	UBERON:0006631	68.41	gold quality
ascending aorta	UBERON:0001496	67.90	gold quality
multicellular organism	UBERON:0000468	67.68	gold quality
fallopian tube	UBERON:0003889	67.66	gold quality
transverse colon	UBERON:0001157	67.38	gold quality
omental fat pad	UBERON:0010414	67.00	gold quality
upper lobe of left lung	UBERON:0008952	66.95	gold quality
popliteal artery	UBERON:0002250	66.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Transfer of miR-4755-5p through extracellular vesicles and particles induces decitabine resistance in recipient cells by targeting CDKN2B. (PMID:36825759)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.