MIR4756

Summary

MIR4756 (microRNA 4756, HGNC:41529) is a microRNA gene on chromosome 20q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616225 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41529
Approved symbol	MIR4756
Name	microRNA 4756
Location	20q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4756
Ensembl gene	ENSG00000265595
Ensembl biotype	miRNA
Entrez	100616225
RNAcentral	URS000075E58C — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577874

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577874 — 1 exons

Exon	Start	End
ENSE00002687513	54068408	54068485

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 80.88.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.88	gold quality
rectum	UBERON:0001052	80.13	gold quality
urinary bladder	UBERON:0001255	74.15	gold quality
stomach	UBERON:0000945	72.30	gold quality
tibial nerve	UBERON:0001323	71.45	gold quality
body of stomach	UBERON:0001161	69.84	gold quality
smooth muscle tissue	UBERON:0001135	69.74	gold quality
intestine	UBERON:0000160	69.01	gold quality
colon	UBERON:0001155	68.32	gold quality
transverse colon	UBERON:0001157	67.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.41	gold quality
small intestine	UBERON:0002108	66.69	gold quality
gall bladder	UBERON:0002110	66.42	gold quality
minor salivary gland	UBERON:0001830	66.21	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.14	gold quality
vagina	UBERON:0000996	64.99	gold quality
fundus of stomach	UBERON:0001160	64.65	gold quality
esophagus mucosa	UBERON:0002469	64.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.15	gold quality
body of pancreas	UBERON:0001150	64.11	gold quality
prostate gland	UBERON:0002367	62.11	gold quality
skin of abdomen	UBERON:0001416	61.57	gold quality
thoracic mammary gland	UBERON:0005200	59.97	gold quality
upper lobe of left lung	UBERON:0008952	57.50	gold quality
Ammon’s horn	UBERON:0001954	56.34	gold quality
left testis	UBERON:0004533	41.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.50

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• In miRNA activity assays using the full-length hap.01 and hap.08 3’-UTR reporter vectors and follow-up validation experiments, hsa-miR-4324 and hsa-miR-4756-5p significantly reduced huntingtin gene (HTT) 3’-UTR reporter activity and endogenous HTT protein levels. (PMID:31296921)
• Integrated network analysis identifies hsa-miR-4756-3p as a regulator of FOXM1 in Triple Negative Breast Cancer. (PMID:31554904)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.