MIR4757

gene

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Also known as hsa-mir-4757

Summary

MIR4757 (microRNA 4757, HGNC:41746) is a microRNA gene on chromosome 2p24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616307 — RefSeq curated summary.

At a glance

Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41746
Approved symbol	MIR4757
Name	microRNA 4757
Location	2p24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4757
Ensembl gene	ENSG00000266738
Ensembl biotype	miRNA
Entrez	100616307
RNAcentral	URS000075B5E8 — ncRNA, 77 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584244

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584244 — 1 exons

Exon	Start	End
ENSE00002729874	19348429	19348505

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 86.70.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
urinary bladder	UBERON:0001255	86.70	gold quality
vermiform appendix	UBERON:0001154	82.06	gold quality
granulocyte	CL:0000094	77.49	gold quality
blood	UBERON:0000178	77.14	gold quality
adrenal tissue	UBERON:0018303	75.36	gold quality
monocyte	CL:0000576	74.67	gold quality
myometrium	UBERON:0001296	73.89	gold quality
omental fat pad	UBERON:0010414	73.73	gold quality
descending thoracic aorta	UBERON:0002345	73.68	gold quality
adipose tissue	UBERON:0001013	73.26	gold quality
gastrocnemius	UBERON:0001388	73.13	gold quality
smooth muscle tissue	UBERON:0001135	72.74	gold quality
heart left ventricle	UBERON:0002084	72.42	gold quality
placenta	UBERON:0001987	72.35	gold quality
small intestine Peyer’s patch	UBERON:0003454	72.26	gold quality
heart	UBERON:0000948	70.94	gold quality
adult mammalian kidney	UBERON:0000082	70.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.65	gold quality
thoracic aorta	UBERON:0001515	70.47	gold quality
ascending aorta	UBERON:0001496	70.44	gold quality
transverse colon	UBERON:0001157	70.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.35	gold quality
Ammon’s horn	UBERON:0001954	69.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.14	gold quality
lower esophagus	UBERON:0013473	69.03	gold quality
body of stomach	UBERON:0001161	68.81	gold quality
right atrium auricular region	UBERON:0006631	68.77	gold quality
stomach	UBERON:0000945	68.53	gold quality
saliva-secreting gland	UBERON:0001044	68.31	gold quality
tibial artery	UBERON:0007610	67.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.

Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): estrogen-receptor negative breast cancer