MIR4758

Summary

MIR4758 (microRNA 4758, HGNC:41836) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616340 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41836
Approved symbol	MIR4758
Name	microRNA 4758
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4758
Ensembl gene	ENSG00000284074
Ensembl biotype	miRNA
Entrez	100616340
RNAcentral	URS000075D767 — ncRNA, 71 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577688

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577688 — 1 exons

Exon	Start	End
ENSE00002728281	62332487	62332557

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 71.20.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
caudate nucleus	UBERON:0001873	71.20	gold quality
heart left ventricle	UBERON:0002084	69.59	gold quality
tibial artery	UBERON:0007610	69.08	gold quality
body of stomach	UBERON:0001161	68.76	gold quality
left coronary artery	UBERON:0001626	68.28	gold quality
right coronary artery	UBERON:0001625	67.48	gold quality
left adrenal gland	UBERON:0001234	67.32	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.11	gold quality
left adrenal gland cortex	UBERON:0035825	66.87	gold quality
omental fat pad	UBERON:0010414	66.77	gold quality
ascending aorta	UBERON:0001496	66.14	gold quality
prostate gland	UBERON:0002367	66.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.22	gold quality
vagina	UBERON:0000996	65.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.84	gold quality
body of uterus	UBERON:0009853	64.73	gold quality
skin of abdomen	UBERON:0001416	64.56	gold quality
esophagus mucosa	UBERON:0002469	64.03	gold quality
thoracic aorta	UBERON:0001515	63.96	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.74	gold quality
skin of leg	UBERON:0001511	63.54	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.33	gold quality
cerebellar hemisphere	UBERON:0002245	62.47	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.30	gold quality
adult mammalian kidney	UBERON:0000082	61.02	gold quality
tibial nerve	UBERON:0001323	60.94	gold quality
urinary bladder	UBERON:0001255	60.88	gold quality
left ovary	UBERON:0002119	60.34	gold quality
upper lobe of left lung	UBERON:0008952	60.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.