MIR4759

Summary

MIR4759 (microRNA 4759, HGNC:41575) is a microRNA gene on chromosome 21q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616243 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41575
Approved symbol	MIR4759
Name	microRNA 4759
Location	21q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4759
Ensembl gene	ENSG00000266133
Ensembl biotype	miRNA
Entrez	100616243
RNAcentral	URS000075E3C6 — ncRNA, 83 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584048

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584048 — 1 exons

Exon	Start	End
ENSE00002722960	26953961	26954043

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 92.13.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	92.13	gold quality
lung	UBERON:0002048	79.60	gold quality
endometrium	UBERON:0001295	78.09	gold quality
gastrocnemius	UBERON:0001388	72.95	gold quality
adult mammalian kidney	UBERON:0000082	72.22	gold quality
intestine	UBERON:0000160	69.71	gold quality
stomach	UBERON:0000945	69.52	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.22	gold quality
heart left ventricle	UBERON:0002084	68.75	gold quality
thoracic mammary gland	UBERON:0005200	66.83	gold quality
heart	UBERON:0000948	66.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.89	gold quality
thoracic aorta	UBERON:0001515	65.79	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.77	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.40	gold quality
right atrium auricular region	UBERON:0006631	65.24	gold quality
skin of leg	UBERON:0001511	64.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.60	gold quality
colon	UBERON:0001155	64.51	gold quality
omental fat pad	UBERON:0010414	64.34	gold quality
transverse colon	UBERON:0001157	64.01	gold quality
right lobe of thyroid gland	UBERON:0001119	64.00	gold quality
ascending aorta	UBERON:0001496	63.96	gold quality
skin of abdomen	UBERON:0001416	63.93	gold quality
body of uterus	UBERON:0009853	63.63	gold quality
descending thoracic aorta	UBERON:0002345	63.53	gold quality
left ovary	UBERON:0002119	63.47	gold quality
left coronary artery	UBERON:0001626	63.40	gold quality
right ovary	UBERON:0002118	63.22	gold quality
left lobe of thyroid gland	UBERON:0001120	62.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.50

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.