MIR4760

Summary

MIR4760 (microRNA 4760, HGNC:41698) is a microRNA gene on chromosome 21q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616148 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41698
Approved symbol	MIR4760
Name	microRNA 4760
Location	21q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4760
Ensembl gene	ENSG00000263973
Ensembl biotype	miRNA
Entrez	100616148
RNAcentral	URS000075EA4A — ncRNA, 80 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585040

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585040 — 1 exons

Exon	Start	End
ENSE00002707623	40212352	40212431

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 75.61.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	75.61	gold quality
monocyte	CL:0000576	72.77	gold quality
Ammon’s horn	UBERON:0001954	63.31	gold quality
nucleus accumbens	UBERON:0001882	62.16	gold quality
caudate nucleus	UBERON:0001873	61.73	gold quality
amygdala	UBERON:0001876	60.28	gold quality
adenohypophysis	UBERON:0002196	59.38	gold quality
lung	UBERON:0002048	59.21	gold quality
corpus callosum	UBERON:0002336	48.85	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.