MIR4761

Summary

MIR4761 (microRNA 4761, HGNC:41591) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616414 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41591
Approved symbol	MIR4761
Name	microRNA 4761
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4761
Ensembl gene	ENSG00000284031
Ensembl biotype	miRNA
Entrez	100616414
RNAcentral	URS000075D5DB — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585066

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585066 — 1 exons

Exon	Start	End
ENSE00002703372	19963753	19963834

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 82.56.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	82.56	gold quality
adrenal tissue	UBERON:0018303	79.09	gold quality
blood	UBERON:0000178	75.93	gold quality
Ammon’s horn	UBERON:0001954	74.57	gold quality
liver	UBERON:0002107	71.79	gold quality
caudate nucleus	UBERON:0001873	71.65	gold quality
gastrocnemius	UBERON:0001388	71.37	gold quality
heart left ventricle	UBERON:0002084	70.03	gold quality
right lobe of liver	UBERON:0001114	69.66	gold quality
vagina	UBERON:0000996	68.01	gold quality
right atrium auricular region	UBERON:0006631	67.95	gold quality
colon	UBERON:0001155	67.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.28	gold quality
ascending aorta	UBERON:0001496	66.55	gold quality
fallopian tube	UBERON:0003889	66.46	gold quality
body of stomach	UBERON:0001161	66.44	gold quality
left adrenal gland	UBERON:0001234	65.80	gold quality
skin of abdomen	UBERON:0001416	65.00	gold quality
left adrenal gland cortex	UBERON:0035825	64.84	gold quality
substantia nigra	UBERON:0002038	64.63	gold quality
transverse colon	UBERON:0001157	64.43	gold quality
putamen	UBERON:0001874	64.29	gold quality
esophagus mucosa	UBERON:0002469	64.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.20	gold quality
minor salivary gland	UBERON:0001830	64.18	gold quality
tibial artery	UBERON:0007610	63.64	gold quality
cerebellar hemisphere	UBERON:0002245	63.42	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.25	gold quality
right frontal lobe	UBERON:0002810	63.12	gold quality
omental fat pad	UBERON:0010414	62.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.