MIR4762

Summary

MIR4762 (microRNA 4762, HGNC:41603) is a microRNA gene on chromosome 22q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616253 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41603
Approved symbol	MIR4762
Name	microRNA 4762
Location	22q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4762
Ensembl gene	ENSG00000264160
Ensembl biotype	miRNA
Entrez	100616253
RNAcentral	URS000075A352 — ncRNA, 75 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585261

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585261 — 1 exons

Exon	Start	End
ENSE00002698598	45760524	45760598

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 97.05.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.05	gold quality
kidney	UBERON:0002113	92.05	gold quality
adrenal tissue	UBERON:0018303	83.54	gold quality
blood	UBERON:0000178	80.10	gold quality
corpus callosum	UBERON:0002336	79.42	gold quality
calcaneal tendon	UBERON:0003701	78.74	gold quality
liver	UBERON:0002107	77.29	gold quality
monocyte	CL:0000576	76.31	gold quality
placenta	UBERON:0001987	76.29	gold quality
stomach	UBERON:0000945	75.84	gold quality
heart left ventricle	UBERON:0002084	73.86	gold quality
islet of Langerhans	UBERON:0000006	73.08	gold quality
gastrocnemius	UBERON:0001388	72.94	gold quality
heart	UBERON:0000948	72.89	gold quality
lung	UBERON:0002048	72.27	gold quality
endometrium	UBERON:0001295	72.26	gold quality
smooth muscle tissue	UBERON:0001135	69.87	gold quality
intestine	UBERON:0000160	69.82	gold quality
body of stomach	UBERON:0001161	69.52	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.42	gold quality
myometrium	UBERON:0001296	68.32	gold quality
hypothalamus	UBERON:0001898	67.97	gold quality
body of pancreas	UBERON:0001150	67.57	gold quality
popliteal artery	UBERON:0002250	66.94	gold quality
tibial artery	UBERON:0007610	66.93	gold quality
fundus of stomach	UBERON:0001160	66.33	gold quality
putamen	UBERON:0001874	66.08	gold quality
left adrenal gland	UBERON:0001234	66.00	gold quality
colon	UBERON:0001155	65.88	gold quality
right lobe of liver	UBERON:0001114	65.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.