MIR4763

Summary

MIR4763 (microRNA 4763, HGNC:41677) is a microRNA gene on chromosome 22q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616143 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41677
Approved symbol	MIR4763
Name	microRNA 4763
Location	22q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4763
Ensembl gene	ENSG00000284175
Ensembl biotype	miRNA
Entrez	100616143
RNAcentral	URS000075D58D — ncRNA, 92 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581461

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581461 — 1 exons

Exon	Start	End
ENSE00002717208	46113566	46113657

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 73.12.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	73.12	gold quality
blood	UBERON:0000178	68.67	gold quality
hypothalamus	UBERON:0001898	67.91	gold quality
right adrenal gland	UBERON:0001233	66.91	gold quality
amygdala	UBERON:0001876	66.90	gold quality
tibial artery	UBERON:0007610	65.80	gold quality
heart left ventricle	UBERON:0002084	65.74	gold quality
right atrium auricular region	UBERON:0006631	65.49	gold quality
left lobe of thyroid gland	UBERON:0001120	64.42	gold quality
left adrenal gland cortex	UBERON:0035825	64.33	gold quality
body of pancreas	UBERON:0001150	63.54	gold quality
body of stomach	UBERON:0001161	63.31	gold quality
left ovary	UBERON:0002119	63.03	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.97	gold quality
nucleus accumbens	UBERON:0001882	61.93	gold quality
right frontal lobe	UBERON:0002810	61.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.72	gold quality
upper lobe of left lung	UBERON:0008952	60.61	gold quality
colon	UBERON:0001155	60.17	gold quality
Ammon’s horn	UBERON:0001954	59.76	gold quality
putamen	UBERON:0001874	59.42	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.41	gold quality
multicellular organism	UBERON:0000468	59.30	gold quality
ascending aorta	UBERON:0001496	59.02	gold quality
skin of abdomen	UBERON:0001416	58.97	gold quality
vagina	UBERON:0000996	58.73	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.73	gold quality
tibial nerve	UBERON:0001323	58.66	gold quality
transverse colon	UBERON:0001157	58.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.