MIR4764

Summary

MIR4764 (microRNA 4764, HGNC:41714) is a microRNA gene on chromosome 22q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616295 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41714
Approved symbol	MIR4764
Name	microRNA 4764
Location	22q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4764
Ensembl gene	ENSG00000266012
Ensembl biotype	miRNA
Entrez	100616295
RNAcentral	URS000075D5BD — miRNA, 88 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580680

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580680 — 1 exons

Exon	Start	End
ENSE00002728396	33436582	33436669

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 83.02.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	83.02	gold quality
kidney	UBERON:0002113	76.91	gold quality
fundus of stomach	UBERON:0001160	76.03	gold quality
gastrocnemius	UBERON:0001388	74.51	gold quality
stomach	UBERON:0000945	74.26	gold quality
blood	UBERON:0000178	74.02	gold quality
adrenal tissue	UBERON:0018303	73.81	gold quality
corpus callosum	UBERON:0002336	73.34	gold quality
endometrium	UBERON:0001295	71.47	gold quality
liver	UBERON:0002107	71.24	gold quality
heart	UBERON:0000948	70.68	gold quality
right atrium auricular region	UBERON:0006631	70.47	gold quality
vagina	UBERON:0000996	68.87	gold quality
tibial artery	UBERON:0007610	68.50	gold quality
body of stomach	UBERON:0001161	68.31	gold quality
tibial nerve	UBERON:0001323	67.74	gold quality
heart left ventricle	UBERON:0002084	67.27	gold quality
lung	UBERON:0002048	67.07	gold quality
right lobe of liver	UBERON:0001114	67.03	gold quality
anterior cingulate cortex	UBERON:0009835	66.33	gold quality
skin of leg	UBERON:0001511	65.48	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.40	gold quality
omental fat pad	UBERON:0010414	65.30	gold quality
putamen	UBERON:0001874	65.10	gold quality
transverse colon	UBERON:0001157	65.01	gold quality
minor salivary gland	UBERON:0001830	64.98	gold quality
Ammon’s horn	UBERON:0001954	64.92	gold quality
adult mammalian kidney	UBERON:0000082	64.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.75	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.