MIR4765

Summary

MIR4765 (microRNA 4765, HGNC:41791) is a microRNA gene on chromosome 2p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616219 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41791
Approved symbol	MIR4765
Name	microRNA 4765
Location	2p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4765
Ensembl gene	ENSG00000265057
Ensembl biotype	miRNA
Entrez	100616219
RNAcentral	URS000075CFB0 — ncRNA, 77 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585007

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585007 — 1 exons

Exon	Start	End
ENSE00002689568	32635255	32635331

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 78.84.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.84	gold quality
Ammon’s horn	UBERON:0001954	78.66	gold quality
adrenal tissue	UBERON:0018303	78.15	gold quality
kidney	UBERON:0002113	77.55	gold quality
heart	UBERON:0000948	77.38	gold quality
monocyte	CL:0000576	76.70	gold quality
lung	UBERON:0002048	75.45	gold quality
endometrium	UBERON:0001295	74.72	gold quality
islet of Langerhans	UBERON:0000006	71.53	gold quality
prostate gland	UBERON:0002367	69.50	gold quality
body of pancreas	UBERON:0001150	69.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.61	gold quality
ascending aorta	UBERON:0001496	64.28	gold quality
left ovary	UBERON:0002119	62.78	gold quality
skin of leg	UBERON:0001511	60.68	gold quality
esophagus mucosa	UBERON:0002469	60.63	gold quality
cerebellar hemisphere	UBERON:0002245	60.55	gold quality
spleen	UBERON:0002106	59.64	gold quality
vagina	UBERON:0000996	58.72	gold quality
pituitary gland	UBERON:0000007	55.87	gold quality
testis	UBERON:0000473	48.95	gold quality
stomach	UBERON:0000945	48.03	gold quality
left testis	UBERON:0004533	45.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells. (PMID:38279497)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.