MIR4766

Summary

MIR4766 (microRNA 4766, HGNC:41680) is a microRNA gene on chromosome 22q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616283 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41680
Approved symbol	MIR4766
Name	microRNA 4766
Location	22q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4766
Ensembl gene	ENSG00000266594
Ensembl biotype	miRNA
Entrez	100616283
RNAcentral	URS000075B16D — miRNA, 76 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584704

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584704 — 1 exons

Exon	Start	End
ENSE00002710455	40813883	40813958

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 89.50.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	89.50	gold quality
duodenum	UBERON:0002114	84.50	gold quality
adrenal tissue	UBERON:0018303	83.37	gold quality
endometrium	UBERON:0001295	82.12	gold quality
bone marrow	UBERON:0002371	81.81	gold quality
blood	UBERON:0000178	79.33	gold quality
placenta	UBERON:0001987	78.78	gold quality
monocyte	CL:0000576	75.18	gold quality
kidney	UBERON:0002113	74.74	gold quality
muscle of leg	UBERON:0001383	73.72	gold quality
gastrocnemius	UBERON:0001388	73.24	gold quality
stomach	UBERON:0000945	72.99	gold quality
calcaneal tendon	UBERON:0003701	72.61	gold quality
islet of Langerhans	UBERON:0000006	71.99	gold quality
lymph node	UBERON:0000029	71.70	gold quality
liver	UBERON:0002107	71.14	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.03	gold quality
heart left ventricle	UBERON:0002084	69.79	gold quality
smooth muscle tissue	UBERON:0001135	69.64	gold quality
body of stomach	UBERON:0001161	69.59	gold quality
right uterine tube	UBERON:0001302	69.51	gold quality
body of pancreas	UBERON:0001150	69.26	gold quality
heart	UBERON:0000948	69.23	gold quality
urinary bladder	UBERON:0001255	68.83	gold quality
right lobe of liver	UBERON:0001114	68.55	gold quality
rectum	UBERON:0001052	68.46	gold quality
fundus of stomach	UBERON:0001160	68.24	gold quality
apex of heart	UBERON:0002098	68.00	gold quality
lung	UBERON:0002048	67.90	gold quality
left adrenal gland	UBERON:0001234	67.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• findings indicated that lncRNA could regulate the progression and chemoresistance of breast cancer via modulating the expression levels of miR-4766-5p and SIRT1, which may have a pivotal role in breast cancer treatment and prognosis prediction. (PMID:29752439)
• Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression. (PMID:34226522)
• LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis. (PMID:36994814)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.