MIR4768

Summary

MIR4768 (microRNA 4768, HGNC:41592) is a microRNA gene on chromosome Xp22.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616249 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41592
Approved symbol	MIR4768
Name	microRNA 4768
Location	Xp22.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4768
Ensembl gene	ENSG00000265465
Ensembl biotype	miRNA
Entrez	100616249
RNAcentral	URS000075AF99 — ncRNA, 74 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585270

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585270 — 1 exons

Exon	Start	End
ENSE00002718731	17425881	17425954

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 90.12.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	90.12	gold quality
sural nerve	UBERON:0015488	89.74	gold quality
adult mammalian kidney	UBERON:0000082	89.35	gold quality
skeletal muscle tissue	UBERON:0001134	87.75	gold quality
kidney	UBERON:0002113	87.05	gold quality
apex of heart	UBERON:0002098	85.73	gold quality
endometrium	UBERON:0001295	83.99	gold quality
lower esophagus mucosa	UBERON:0035834	83.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.85	gold quality
rectum	UBERON:0001052	82.09	gold quality
right uterine tube	UBERON:0001302	80.88	gold quality
prostate gland	UBERON:0002367	79.25	gold quality
fundus of stomach	UBERON:0001160	78.87	gold quality
prefrontal cortex	UBERON:0000451	78.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	77.94	gold quality
left adrenal gland cortex	UBERON:0035825	77.00	gold quality
hypothalamus	UBERON:0001898	76.33	gold quality
ectocervix	UBERON:0012249	76.27	gold quality
right adrenal gland cortex	UBERON:0035827	76.26	gold quality
adrenal gland	UBERON:0002369	76.22	gold quality
left coronary artery	UBERON:0001626	76.04	gold quality
right coronary artery	UBERON:0001625	75.84	gold quality
left adrenal gland	UBERON:0001234	75.77	gold quality
urinary bladder	UBERON:0001255	75.74	gold quality
right lobe of thyroid gland	UBERON:0001119	75.72	gold quality
muscle of leg	UBERON:0001383	75.48	gold quality
stomach	UBERON:0000945	75.46	gold quality
tibial nerve	UBERON:0001323	75.11	gold quality
calcaneal tendon	UBERON:0003701	75.00	gold quality
body of uterus	UBERON:0009853	74.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• It has been shown that the expression of miR-29a as well as miR-548a was positively correlated with tumor stage and lymph node metastasis, whereas the expression of miR-4768-3p was negatively correlated with lymph node metastasis. (PMID:28430523)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.