MIR4769

Summary

MIR4769 (microRNA 4769, HGNC:41694) is a microRNA gene on chromosome Xp11.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616147 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41694
Approved symbol	MIR4769
Name	microRNA 4769
Location	Xp11.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4769
Ensembl gene	ENSG00000263858
Ensembl biotype	miRNA
Entrez	100616147
RNAcentral	URS0000759ED5 — ncRNA, 77 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584126

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584126 — 1 exons

Exon	Start	End
ENSE00002696796	47587429	47587505

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 95.12.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.12	gold quality
lung	UBERON:0002048	75.45	gold quality
blood	UBERON:0000178	74.04	gold quality
intestine	UBERON:0000160	72.31	gold quality
monocyte	CL:0000576	72.12	gold quality
adult mammalian kidney	UBERON:0000082	70.54	gold quality
gall bladder	UBERON:0002110	70.43	gold quality
liver	UBERON:0002107	69.65	gold quality
islet of Langerhans	UBERON:0000006	69.27	gold quality
right frontal lobe	UBERON:0002810	69.07	gold quality
endometrium	UBERON:0001295	67.76	gold quality
left adrenal gland	UBERON:0001234	67.74	gold quality
tibial artery	UBERON:0007610	66.79	gold quality
nucleus accumbens	UBERON:0001882	66.72	gold quality
Ammon’s horn	UBERON:0001954	66.39	gold quality
hypothalamus	UBERON:0001898	65.57	gold quality
skin of leg	UBERON:0001511	65.37	gold quality
omental fat pad	UBERON:0010414	65.20	gold quality
putamen	UBERON:0001874	63.83	gold quality
transverse colon	UBERON:0001157	63.55	gold quality
ascending aorta	UBERON:0001496	63.22	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.80	gold quality
brain	UBERON:0000955	62.70	gold quality
cerebellar hemisphere	UBERON:0002245	62.65	gold quality
substantia nigra	UBERON:0002038	62.10	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.93	gold quality
amygdala	UBERON:0001876	61.61	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.61	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	61.12	gold quality
vagina	UBERON:0000996	61.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.