MIR4771-2

Summary

MIR4771-2 (microRNA 4771-2, HGNC:41774) is a microRNA gene on chromosome 2q13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616165 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41774
Approved symbol	MIR4771-2
Name	microRNA 4771-2
Location	2q13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4771-2
Ensembl gene	ENSG00000266063
Ensembl biotype	miRNA
Entrez	100616165
RNAcentral	URS000075ECED — ncRNA, 74 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577758

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577758 — 1 exons

Exon	Start	End
ENSE00002686396	111771061	111771134

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 81.99.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	81.99	gold quality
calcaneal tendon	UBERON:0003701	75.67	gold quality
lower esophagus mucosa	UBERON:0035834	75.18	gold quality
lymph node	UBERON:0000029	74.55	gold quality
bone marrow	UBERON:0002371	72.97	gold quality
blood	UBERON:0000178	72.33	gold quality
adrenal tissue	UBERON:0018303	71.22	gold quality
tonsil	UBERON:0002372	69.88	gold quality
muscle of leg	UBERON:0001383	69.22	gold quality
monocyte	CL:0000576	68.53	gold quality
gastrocnemius	UBERON:0001388	68.13	gold quality
placenta	UBERON:0001987	67.65	gold quality
endometrium	UBERON:0001295	66.78	gold quality
fundus of stomach	UBERON:0001160	66.42	gold quality
ectocervix	UBERON:0012249	65.79	gold quality
smooth muscle tissue	UBERON:0001135	65.25	gold quality
heart left ventricle	UBERON:0002084	64.99	gold quality
gall bladder	UBERON:0002110	64.92	gold quality
heart	UBERON:0000948	64.35	gold quality
left adrenal gland cortex	UBERON:0035825	64.16	gold quality
liver	UBERON:0002107	63.83	gold quality
stomach	UBERON:0000945	63.77	gold quality
body of pancreas	UBERON:0001150	63.36	gold quality
endocervix	UBERON:0000458	63.22	gold quality
rectum	UBERON:0001052	63.11	gold quality
left coronary artery	UBERON:0001626	63.11	gold quality
adrenal gland	UBERON:0002369	63.00	gold quality
body of stomach	UBERON:0001161	62.91	gold quality
urinary bladder	UBERON:0001255	62.75	gold quality
right uterine tube	UBERON:0001302	62.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): MIR4771-1 (ENSG00000264793)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.