MIR4772

Summary

MIR4772 (microRNA 4772, HGNC:41741) is a microRNA gene on chromosome 2q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616157 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41741
Approved symbol	MIR4772
Name	microRNA 4772
Location	2q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4772
Ensembl gene	ENSG00000264764
Ensembl biotype	miRNA
Entrez	100616157
RNAcentral	URS000075D5D4 — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581495

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581495 — 1 exons

Exon	Start	End
ENSE00002715910	102432289	102432366

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 94.93.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	94.93	gold quality
vermiform appendix	UBERON:0001154	90.07	gold quality
blood	UBERON:0000178	84.02	gold quality
right lung	UBERON:0002167	78.97	gold quality
liver	UBERON:0002107	77.35	gold quality
monocyte	CL:0000576	76.36	gold quality
leukocyte	CL:0000738	75.11	gold quality
lymph node	UBERON:0000029	74.92	gold quality
right ovary	UBERON:0002118	74.85	gold quality
left adrenal gland cortex	UBERON:0035825	74.43	gold quality
gall bladder	UBERON:0002110	73.17	gold quality
gastrocnemius	UBERON:0001388	71.57	gold quality
anterior cingulate cortex	UBERON:0009835	71.55	gold quality
heart left ventricle	UBERON:0002084	71.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.46	gold quality
hypothalamus	UBERON:0001898	70.11	gold quality
left uterine tube	UBERON:0001303	69.99	gold quality
body of stomach	UBERON:0001161	69.40	gold quality
stomach	UBERON:0000945	68.72	gold quality
omental fat pad	UBERON:0010414	68.65	gold quality
adipose tissue	UBERON:0001013	68.58	gold quality
spleen	UBERON:0002106	68.47	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.32	gold quality
fundus of stomach	UBERON:0001160	67.92	gold quality
ascending aorta	UBERON:0001496	67.81	gold quality
left adrenal gland	UBERON:0001234	67.32	gold quality
thoracic aorta	UBERON:0001515	67.06	gold quality
granulocyte	CL:0000094	67.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.02	gold quality
right lobe of liver	UBERON:0001114	67.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Reduced expression of serum exosomal miR-4772-3p is a prognostic biomarker for tumor recurrence in stage II and stage III colon cancer patients. (PMID:27788488)
• [MiR-4772 modulates tumor immune microenvironment by regulating immune- related genes in ovarian cancer]. (PMID:36504056)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.