MIR4773-2

Summary

MIR4773-2 (microRNA 4773-2, HGNC:41790) is a microRNA gene on chromosome 2q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616418 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41790
Approved symbol	MIR4773-2
Name	microRNA 4773-2
Location	2q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4773-2
Ensembl gene	ENSG00000283569
Ensembl biotype	miRNA
Entrez	100616418
RNAcentral	URS000075B261 — miRNA, 78 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637203

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637203 — 1 exons

Exon	Start	End
ENSE00003797413	151368334	151368411

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 70.25.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	70.25	gold quality
blood	UBERON:0000178	65.86	gold quality
gastrocnemius	UBERON:0001388	64.44	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.48	gold quality
upper lobe of left lung	UBERON:0008952	62.34	gold quality
heart	UBERON:0000948	62.06	gold quality
skin of leg	UBERON:0001511	61.75	gold quality
transverse colon	UBERON:0001157	61.04	gold quality
omental fat pad	UBERON:0010414	60.72	gold quality
skin of abdomen	UBERON:0001416	60.11	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.10	gold quality
right atrium auricular region	UBERON:0006631	59.72	gold quality
left lobe of thyroid gland	UBERON:0001120	59.53	gold quality
body of stomach	UBERON:0001161	58.97	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.21	gold quality
ascending aorta	UBERON:0001496	57.08	gold quality
esophagus mucosa	UBERON:0002469	56.69	gold quality
spleen	UBERON:0002106	56.66	gold quality
vagina	UBERON:0000996	56.62	gold quality
tibial nerve	UBERON:0001323	55.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	55.79	gold quality
putamen	UBERON:0001874	55.01	gold quality
lower esophagus muscularis layer	UBERON:0035833	53.29	gold quality
thoracic mammary gland	UBERON:0005200	52.97	gold quality
left testis	UBERON:0004533	31.80	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.