MIR4774

Summary

MIR4774 (microRNA 4774, HGNC:41873) is a microRNA gene on chromosome 2q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616356 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41873
Approved symbol	MIR4774
Name	microRNA 4774
Location	2q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4774
Ensembl gene	ENSG00000265694
Ensembl biotype	miRNA
Entrez	100616356
RNAcentral	URS000075A2B9 — miRNA, 76 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583305

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583305 — 1 exons

Exon	Start	End
ENSE00002730006	168582943	168583018

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 88.65.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	88.65	gold quality
vermiform appendix	UBERON:0001154	83.64	gold quality
blood	UBERON:0000178	81.82	gold quality
kidney	UBERON:0002113	80.46	gold quality
calcaneal tendon	UBERON:0003701	80.30	gold quality
adult mammalian kidney	UBERON:0000082	79.84	gold quality
stomach	UBERON:0000945	79.31	gold quality
endometrium	UBERON:0001295	78.14	gold quality
liver	UBERON:0002107	76.74	gold quality
monocyte	CL:0000576	75.10	gold quality
heart	UBERON:0000948	74.80	gold quality
corpus callosum	UBERON:0002336	74.29	gold quality
intestine	UBERON:0000160	73.73	gold quality
right lobe of thyroid gland	UBERON:0001119	71.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.28	gold quality
body of stomach	UBERON:0001161	70.52	gold quality
colon	UBERON:0001155	70.24	gold quality
prefrontal cortex	UBERON:0000451	69.81	gold quality
left adrenal gland cortex	UBERON:0035825	69.76	gold quality
lung	UBERON:0002048	69.71	gold quality
heart left ventricle	UBERON:0002084	68.90	gold quality
myometrium	UBERON:0001296	67.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.43	gold quality
right atrium auricular region	UBERON:0006631	67.19	gold quality
frontal cortex	UBERON:0001870	66.96	gold quality
transverse colon	UBERON:0001157	66.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.55	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.38	gold quality
prostate gland	UBERON:0002367	66.26	gold quality
omental fat pad	UBERON:0010414	65.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.89

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.