MIR4775

Summary

MIR4775 (microRNA 4775, HGNC:41885) is a microRNA gene on chromosome 2q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616361 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41885
Approved symbol	MIR4775
Name	microRNA 4775
Location	2q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4775
Ensembl gene	ENSG00000284079
Ensembl biotype	miRNA
Entrez	100616361
RNAcentral	URS000075B648 — ncRNA, 75 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581168

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581168 — 1 exons

Exon	Start	End
ENSE00002721295	207754807	207754881

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 85.47.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.47	gold quality
skeletal muscle tissue	UBERON:0001134	74.45	gold quality
body of stomach	UBERON:0001161	73.97	gold quality
spleen	UBERON:0002106	71.19	gold quality
adult mammalian kidney	UBERON:0000082	69.88	gold quality
tibial nerve	UBERON:0001323	69.82	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.42	gold quality
muscle of leg	UBERON:0001383	67.28	gold quality
blood	UBERON:0000178	66.47	gold quality
anterior cingulate cortex	UBERON:0009835	66.24	gold quality
thoracic mammary gland	UBERON:0005200	65.18	gold quality
tibial artery	UBERON:0007610	64.38	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.59	gold quality
gastrocnemius	UBERON:0001388	62.99	gold quality
heart	UBERON:0000948	61.88	gold quality
intestine	UBERON:0000160	61.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.05	gold quality
colon	UBERON:0001155	60.16	gold quality
heart left ventricle	UBERON:0002084	60.07	gold quality
cerebellar hemisphere	UBERON:0002245	58.51	gold quality
prostate gland	UBERON:0002367	57.73	gold quality
skin of leg	UBERON:0001511	56.88	gold quality
brain	UBERON:0000955	56.23	gold quality
ascending aorta	UBERON:0001496	55.37	gold quality
caudate nucleus	UBERON:0001873	54.03	gold quality
substantia nigra	UBERON:0002038	53.98	gold quality
skin of abdomen	UBERON:0001416	50.33	gold quality
right frontal lobe	UBERON:0002810	48.12	gold quality
nucleus accumbens	UBERON:0001882	48.01	gold quality
left ovary	UBERON:0002119	46.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-4775 promotes CRC metastasis and recurrence in a Smad7/TGFbeta signaling-dependent manner, providing a new therapeutic target for inhibiting the metastasis or recurrence of the disease. (PMID:28095858)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.